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pou3f3a POU class 3 homeobox 3a [ Danio rerio (zebrafish) ]

Gene ID: 30386, updated on 28-Oct-2024

Summary

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Official Symbol
pou3f3aprovided by ZNC
Official Full Name
POU class 3 homeobox 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-220
See related
Ensembl:ENSDARG00000042032 AllianceGenome:ZFIN:ZDB-GENE-980526-220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp12; pou12; brn1.1; BRN-1.1; ZP12POU; wu:fc33a11
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within brain development and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in central nervous system; neural tube; neurons; pharyngeal arch; and pronephric duct. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See pou3f3a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6658594..6661699, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6680609..6683714, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-118h3.6 Neighboring gene G protein-coupled receptor 45 Neighboring gene uncharacterized LOC137496442 Neighboring gene uncharacterized LOC137496443

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Developmental expression of class III and IV POU domain genes in the zebrafish. Sampath K, et al. Biochem Biophys Res Commun, 1996 Feb 15. PMID 8605028
  2. Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. Petit D, et al. J Biol Chem, 2010 Dec 3. PMID 20855889, Free PMC Article
  3. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Hauptmann G, et al. Dev Dyn, 2000 Jun. PMID 10842361
  4. Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Barske L, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958671, Free PMC Article
  5. The helix-loop-helix protein id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Rodriguez Viales R, et al. Stem Cells, 2015 Mar. PMID 25376791

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC192422

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
POU domain, class 3, transcription factor 3-A
Names
POU domain gene 12
POU domain protein 12
POU domain protein zp-12
ZP-12
brain POU domain gene 1.1
brain-1.1
brain-specific homeobox/POU domain protein 1.1
class III POU domain protein taichi
zfbrn-1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312687.1 → NP_001299616.1  POU domain, class 3, transcription factor 3-A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC058318, BX842683
    UniProtKB/Swiss-Prot
    B0S7I5, B0S7I6, B0S7I7, B5DDP9, O57514, P56224, Q6IS23, Q6NZU9, Q6PE22, Q7ZU57, Q90433, Q90436
    Related
    ENSDARP00000103222.3, ENSDART00000113914.4
    Conserved Domains (2) summary
    smart00352
    Location:242 → 316
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:337 → 390
    Homeobox; Homeobox domain

  2. NM_131150.2 → NP_571225.2  POU domain, class 3, transcription factor 3-A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC058318, BC065961, BX842683
    UniProtKB/Swiss-Prot
    P56224
    Related
    ENSDARP00000061592.2, ENSDART00000061593.3
    Conserved Domains (2) summary
    smart00352
    Location:242 → 316
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:337 → 390
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    6658594..6661699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56224.2 GenPept UniProtKB/Swiss-Prot:P56224

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