nr2f2 nuclear receptor subfamily 2, group F, member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr2f2provided by ZNC
Official Full Name: nuclear receptor subfamily 2, group F, member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-252
See related: Ensembl:ENSDARG00000040926 AllianceGenome:ZFIN:ZDB-GENE-990415-252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: svp40; COUP-TF; svp[40]; wu:fc94g08
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor activity; and retinoic acid binding activity. Acts upstream of with a positive effect on venous endothelial cell fate commitment. Acts upstream of or within circulatory system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; head; hindbrain neural keel; midbrain neural tube; and neural crest cell. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (23868650..23878764, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (23882118..23888838, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development.
Title: Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development.
Using nr2f1a and nr2f2 mutants, we find that Nr2f1a and Nr2f2 have redundant requirements restricting ventricular cardiomyocyte number and promoting development of the posterior pharyngeal muscles.
Title: Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors.
Sox7/18 factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
Title: SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
absence of NR2F2 in zebrafish resulted in distinct vascular defects including loss of venous marker expression, major trunk vessel fusion and vascular leakage.
Title: Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis.

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General gene information

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Markers

fi45h01.x1 (e-PCR)
- UniSTS:197565

fb53g06.y1 (e-PCR)
- UniSTS:190688

fc94g08.x1 (e-PCR)
- UniSTS:204015

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphatic endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect venous endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COUP transcription factor 2

Names: COUP-TFII; COUPTFbeta; seven-up related 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131183.2 → NP_571258.1 COUP transcription factor 2

See identical proteins and their annotated locations for NP_571258.1

Status: VALIDATED

Source sequence(s)

BX569787, BX936364

UniProtKB/TrEMBL

A0A8M1PAR6, Q91430

Related

ENSDARP00000107285.2, ENSDART00000130163.4

Conserved Domains (2) summary

cd06948
Location:185 → 420

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:87 → 159

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers