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mxi1 max interactor 1, dimerization protein [ Danio rerio (zebrafish) ]

Gene ID: 30485, updated on 2-Nov-2024

Summary

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Official Symbol
mxi1provided by ZNC
Official Full Name
max interactor 1, dimerization proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-151
See related
Ensembl:ENSDARG00000040884 AllianceGenome:ZFIN:ZDB-GENE-990415-151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb16b12; fb55f03; wu:fb16b12; wu:fb55f03; wu:fd06a08; wu:fz74f10; etID309773.22
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including axial chorda mesoderm; median fin fold; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to human MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mxi1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (30330545..30361078)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (30381368..30409337)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene stonustoxin subunit beta-like Neighboring gene adducin 3 (gamma) a Neighboring gene uncharacterized LOC137488972 Neighboring gene V-set domain-containing T-cell activation inhibitor 1-like Neighboring gene si:dkey-169i5.4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of the murine Mxi1 cDNA. Shimizu E, et al. Gene, 1995 Jan 23. PMID 7835718
  2. Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Schreiber-Agus N, et al. Oncogene, 1994 Nov. PMID 7936639
  3. Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Ruuskanen JO, et al. Mol Biol Evol, 2004 Jan. PMID 12949138
  4. Phylogenetic analysis of zebrafish basic helix-loop-helix transcription factors. Wang Y, et al. J Mol Evol, 2009 Jun. PMID 19449054
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
max-interacting protein 1
Names
adducin 3 (gamma)
max interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308638.1 → NP_001295567.1  max-interacting protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of the first exon of variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BX649448, EB839845, EB895068
    UniProtKB/Swiss-Prot
    P50541
    UniProtKB/TrEMBL
    A0A8M1P6J8, A3KQG1
    Related
    ENSDARP00000059922.3, ENSDART00000059923.4
    Conserved Domains (1) summary
    smart00353
    Location:61 → 113
    HLH; helix loop helix domain

  2. NM_131237.2 → NP_571312.2  max-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX649448, EB895068
    UniProtKB/Swiss-Prot
    P50541
    UniProtKB/TrEMBL
    A0A8M1PBL3, A3KQG0
    Related
    ENSDARP00000095521.4, ENSDART00000104751.6
    Conserved Domains (1) summary
    smart00353
    Location:112 → 164
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    30330545..30361078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216253.1 → XP_068072354.1  max-interacting protein 1 isoform X1

  2. XM_068216254.1 → XP_068072355.1  max-interacting protein 1 isoform X2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395120.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    36879..64848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50541.1 GenPept UniProtKB/Swiss-Prot:P50541

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