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hbae3 hemoglobin alpha embryonic-3 [ Danio rerio (zebrafish) ]

Gene ID: 30601, updated on 28-Oct-2024

Summary

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Official Symbol
hbae3provided by ZNC
Official Full Name
hemoglobin alpha embryonic-3provided by ZNC
Primary source
ZFIN:ZDB-GENE-990706-3
See related
Ensembl:ENSDARG00000079305 AllianceGenome:ZFIN:ZDB-GENE-990706-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
globin; fb57a06; zgc:86867; wu:fb57a06; si:by119c3.4
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to act upstream of or within oxygen transport. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in hematopoietic cell; hematopoietic system; mesoderm; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See hbae3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55146590..55147767, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54891994..54893165, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin, beta embryonic 1.3 Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Two-color fluorescent in situ hybridization using chromogenic substrates in zebrafish. Schumacher JA, et al. Biotechniques, 2014 Nov. PMID 25391914, Free PMC Article
  2. Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells. Petrova NV, et al. Biochimie, 2021 Feb. PMID 33321129
  3. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Mercurio S, et al. Haematologica, 2015 Jun. PMID 25795718, Free PMC Article
  4. Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters. Kovina AP, et al. Mol Biol Evol, 2017 Jun 1. PMID 28333290
  5. Characterization of embryonic globin genes of the zebrafish. Brownlie A, et al. Dev Biol, 2003 Mar 1. PMID 12618133

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oxygen transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hemoglobin alpha embryonic-3
Names
dZ118J2.11 (novel alpha-globin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183066.3 → NP_898889.2  hemoglobin alpha embryonic-3

    See identical proteins and their annotated locations for NP_898889.2

    Status: VALIDATED

    Source sequence(s)
    CU464181
    UniProtKB/TrEMBL
    A0A8N7XJ27, F1Q6U4, Q6IQA3, Q7ZYZ4
    Related
    ENSDARP00000103718.2, ENSDART00000109016.2
    Conserved Domains (1) summary
    cd08927
    Location:3 → 143
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    55146590..55147767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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