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Klf12 KLF transcription factor 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306110, updated on 2-Nov-2024

Summary

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Official Symbol
Klf12provided by RGD
Official Full Name
KLF transcription factor 12provided by RGD
Primary source
RGD:1309204
See related
EnsemblRapid:ENSRNOG00000009145 AllianceGenome:RGD:1309204
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Orthologous to human KLF12 (KLF transcription factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 108.1), Kidney (RPKM 56.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klf12 in Genome Data Viewer
Location:
15q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (83037548..83469998, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (76628778..77062000, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (84316986..84748549, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097060 Neighboring gene uncharacterized LOC102553927 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC103693766 Neighboring gene uncharacterized LOC134482159 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Suda S, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16615998
  2. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Imhof A, et al. Mol Cell Biol, 1999 Jan. PMID 9858544, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Krueppel-like factor 12
Names
Kruppel-like factor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107281.1 → NP_001100751.1  Krueppel-like factor 12

    See identical proteins and their annotated locations for NP_001100751.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HU64, D3ZG44
    Related
    ENSRNOP00000012424.8, ENSRNOT00000012424.9
    Conserved Domains (3) summary
    COG5048
    Location:242 → 418
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    83037548..83469998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093393.2 → XP_038949321.1  Krueppel-like factor 12 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AMS3, D3ZG44
    Related
    ENSRNOP00000109858.1, ENSRNOT00000162907.1
    Conserved Domains (4) summary
    COG5048
    Location:195 → 371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:333 → 358
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:12 → 194
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  2. XM_039093390.2 → XP_038949318.1  Krueppel-like factor 12 isoform X6

    UniProtKB/TrEMBL
    D3ZG44
    Conserved Domains (4) summary
    COG5048
    Location:206 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:8 → 205
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  3. XM_006252410.5 → XP_006252472.1  Krueppel-like factor 12 isoform X5

    See identical proteins and their annotated locations for XP_006252472.1

    UniProtKB/TrEMBL
    A0A0G2K610, A6HU63, D3ZG44
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  4. XM_039093395.1 → XP_038949323.1  Krueppel-like factor 12 isoform X8

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  5. XM_017599716.2 → XP_017455205.1  Krueppel-like factor 12 isoform X6

    UniProtKB/TrEMBL
    D3ZG44
    Conserved Domains (4) summary
    COG5048
    Location:206 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:8 → 205
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  6. XM_017599718.2 → XP_017455207.1  Krueppel-like factor 12 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AMS3, D3ZG44
    Conserved Domains (4) summary
    COG5048
    Location:195 → 371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:333 → 358
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:12 → 194
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  7. XM_006252409.4 → XP_006252471.1  Krueppel-like factor 12 isoform X5

    See identical proteins and their annotated locations for XP_006252471.1

    UniProtKB/TrEMBL
    A0A0G2K610, A6HU63, D3ZG44
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  8. XM_063274334.1 → XP_063130404.1  Krueppel-like factor 12 isoform X8

    Related
    ENSRNOP00000094732.2, ENSRNOT00000115385.2

  9. XM_063274333.1 → XP_063130403.1  Krueppel-like factor 12 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AMS3

  10. XM_039093386.1 → XP_038949314.1  Krueppel-like factor 12 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K610, A6HU63, D3ZG44
    Related
    ENSRNOP00000073633.1, ENSRNOT00000090009.3
    Conserved Domains (4) summary
    COG5048
    Location:225 → 401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:363 → 388
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:27 → 224
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  11. XM_063274331.1 → XP_063130401.1  Krueppel-like factor 12 isoform X6

  12. XM_039093384.2 → XP_038949312.1  Krueppel-like factor 12 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:284 → 460
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:422 → 447
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:101 → 283
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  13. XM_039093383.2 → XP_038949311.1  Krueppel-like factor 12 isoform X3

    Related
    ENSRNOP00000099671.1, ENSRNOT00000152113.1
    Conserved Domains (4) summary
    COG5048
    Location:314 → 490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:408 → 430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:452 → 477
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:116 → 313
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  14. XM_039093388.2 → XP_038949316.1  Krueppel-like factor 12 isoform X6

    UniProtKB/TrEMBL
    D3ZG44
    Related
    ENSRNOP00000109863.1, ENSRNOT00000150382.1
    Conserved Domains (4) summary
    COG5048
    Location:206 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 322
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:344 → 369
    zf-H2C2_2; Zinc-finger double domain
    cd21441
    Location:8 → 205
    KLF12_N; N-terminal domain of Kruppel-like factor 12

  15. XM_039093394.2 → XP_038949322.1  Krueppel-like factor 12 isoform X8

    Conserved Domains (4) summary
    COG5048
    Location:175 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:269 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313 → 338
    zf-H2C2_2; Zinc-finger double domain
    cl40450
    Location:1 → 174
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

  16. XM_063274328.1 → XP_063130398.1  Krueppel-like factor 12 isoform X1

  17. XM_063274326.1 → XP_063130396.1  Krueppel-like factor 12 isoform X1

  18. XM_063274327.1 → XP_063130397.1  Krueppel-like factor 12 isoform X1

  19. XM_063274329.1 → XP_063130399.1  Krueppel-like factor 12 isoform X2

RNA

  1. XR_005493737.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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