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bmp4 bone morphogenetic protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 30612, updated on 30-Jun-2024

Summary

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Official Symbol
bmp4provided by ZNC
Official Full Name
bone morphogenetic protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-980528-2059
See related
Ensembl:ENSDARG00000019995 AllianceGenome:ZFIN:ZDB-GENE-980528-2059
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bmp-4; zbmp-4; zgc:100779
Summary
Predicted to enable BMP receptor binding activity and cytokine activity. Acts upstream of or within several processes, including animal organ development; determination of bilateral symmetry; and embryonic morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; inner ear; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See bmp4 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (50564103..50586135)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (50485034..50507066)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene gastrula zinc finger protein XlCGF71.1-like Neighboring gene zgc:113377 Neighboring gene DDHD domain containing 1a Neighboring gene FERM domain containing kindlin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Use of PTC124 for nonsense suppression therapy targeting BMP4 nonsense variants in vitro and the bmp4st72 allele in zebrafish. Krall M, et al. PLoS One, 2019. PMID 31017898, Free PMC Article
  2. Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish. Dumitrescu E, et al. Environ Pollut, 2017 Oct. PMID 28623802
  3. Bone morphogenetic protein-4 expression characterizes inductive boundaries in organs of developing zebrafish. Chin AJ, et al. Dev Genes Evol, 1997 Jul. PMID 27747403
  4. Comparative genomics on BMP4 orthologs. Katoh Y, et al. Int J Oncol, 2005 Aug. PMID 16010442
  5. Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Shentu H, et al. Genesis, 2003 Nov. PMID 14595833

See all (439) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway.
    Title: Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway.
  2. lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
    Title: lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
  3. Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish.
    Title: Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish.
  4. pouC binds a bmp4 intronic regulatory element to mediate transcriptional activation
    Title: pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.
  5. Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
    Title: Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.
  6. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a.
    Title: FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.
  7. we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart
    Title: Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry.
  8. Results show that BMP4 down-regulates fshr while up-regulating lhr expression.
    Title: Differential regulation of gonadotropin receptors by bone morphogenetic proteins in the zebrafish ovary.
  9. These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.
    Title: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
  10. Id2a and Bmp4 misexpression resulted in similar ectomesenchyme defects;misexpression of Bmp4 in migrating Cranial neural crest cells inhibits ectomesenchyme formation.
    Title: Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC100779

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway involved in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cloaca development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of ventral identity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within determination of ventral identity IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within determination of ventral identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic anal fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within heart jogging IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within notochord cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proepicardium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bone morphogenetic protein 4
Names
etID309887.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131342.2 → NP_571417.1  bone morphogenetic protein 4 precursor

    See identical proteins and their annotated locations for NP_571417.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078423
    UniProtKB/TrEMBL
    O57574
    Related
    ENSDARP00000069635.3, ENSDART00000075150.5
    Conserved Domains (2) summary
    smart00204
    Location:300 → 400
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:35 → 272
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    50564103..50586135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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