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pth1r parathyroid hormone 1 receptor [ Danio rerio (zebrafish) ]

Gene ID: 30629, updated on 2-Nov-2024

Summary

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Official Symbol
pth1rprovided by ZNC
Official Full Name
parathyroid hormone 1 receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-991123-8
See related
Ensembl:ENSDARG00000020957 AllianceGenome:ZFIN:ZDB-GENE-991123-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pthr1; pth1ra; zPTH1R
Summary
Enables parathyroid hormone receptor activity and peptide hormone binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; dorsal aorta development; and positive regulation of inositol phosphate biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including bone tissue; gill; liver; opercular flap; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pth1r in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2290148..2451181, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (1947342..2108375, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 13 Neighboring gene transmembrane inner ear Neighboring gene microRNA 460 Neighboring gene corticotropin-releasing factor receptor 2 Neighboring gene myosin, light chain 13 Neighboring gene translation initiation factor eIF2B subunit epsilon-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese. Yamaguchi T, et al. J Bone Miner Res, 2011 Jul. PMID 21404329
  2. The secretin G-protein-coupled receptor family: teleost receptors. Cardoso JC, et al. J Mol Endocrinol, 2005 Jun. PMID 15956345
  3. The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish. Gleason MR, et al. Proc Natl Acad Sci U S A, 2009 Dec 15. PMID 19934034, Free PMC Article
  4. Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors. Hoare SR, et al. Curr Pharm Des, 2001 May. PMID 11375776
  5. Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development. Gray C, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23559631

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch dependent.
    Title: Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables parathyroid hormone receptor activity IDA
Inferred from Direct Assay
more info
  
enables parathyroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IDA
Inferred from Direct Assay
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dorsal aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
parathyroid hormone/parathyroid hormone-related peptide receptor
Names
parathyroid hormone 1 receptor a
parathyroid hormone receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131357.1 → NP_571432.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_571432.1

    Status: PROVISIONAL

    Source sequence(s)
    AF132084
    UniProtKB/TrEMBL
    B3DFY8, Q9PVD3
    Related
    ENSDARP00000091807.2, ENSDART00000101033.4
    Conserved Domains (2) summary
    pfam00002
    Location:141 → 409
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:60 → 125
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    2290148..2451181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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