mdm2 MDM2 proto-oncogene [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mdm2provided by ZNC
Official Full Name: MDM2 proto-oncogeneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-153
See related: Ensembl:ENSDARG00000033443 AllianceGenome:ZFIN:ZDB-GENE-990415-153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu923; zgc:109834
Summary: Predicted to enable p53 binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (23125732..23135272)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (23404700..23414304)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-seq analysis suggested important roles of Dhx15 in chromatin and nucleosome assembly and regulation of the Mdm2-p53 pathway.
Title: Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.
mutant Mdm2 was unable to rescue a p53-induced apoptotic phenotype.
Title: Dysfunction of the MDM2/p53 axis is linked to premature aging.
Data indicate that knockdown of the Mdm2 and Mdm4 caused dramatic accumulation of mutant p53 protein.
Title: Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish.
Data show that liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
Title: Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc16b11.x1 (e-PCR)
- UniSTS:203828

mdm2 (e-PCR), detects polymorphism
- UniSTS:186988

fc09h12.y1 (e-PCR)
- UniSTS:192412

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric glomerulus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein stability	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to X-ray	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Mdm2

Names: MDM2 oncogene, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase Mdm2; double minute 2 protein; etID309863.4; murine double minute 2 homolog; p53-binding protein Mdm2; transformed 3T3 cell double minute 2 homolog

XP_005164901.1

EC 2.3.2.27

XP_005164902.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365432.1 → NP_001352361.1 E3 ubiquitin-protein ligase Mdm2 isoform 1

Status: VALIDATED

Source sequence(s)

AL929141

UniProtKB/TrEMBL

A0A0R4ISQ1, A0A8M2BC69, Q561Z0

Conserved Domains (3) summary

pfam00641
Location:286 → 312

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:21 → 82

SWIB; SWIB/MDM2 domain

cd16783
Location:430 → 486

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
NM_131364.3 → NP_571439.3 E3 ubiquitin-protein ligase Mdm2 isoform 2

Status: VALIDATED

Source sequence(s)

AL929141, AL935183

UniProtKB/TrEMBL

Q561Z0

Related

ENSDARP00000072320.4, ENSDART00000077854.6

Conserved Domains (3) summary

pfam00641
Location:275 → 301

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:21 → 82

SWIB; SWIB/MDM2 domain

cd16783
Location:419 → 475

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

23125732..23135272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164844.4 → XP_005164901.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

See identical proteins and their annotated locations for XP_005164901.1

UniProtKB/TrEMBL

A0A0R4ISQ1, A0A8M2BC69, Q561Z0

Conserved Domains (3) summary

pfam00641
Location:286 → 312

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:21 → 82

SWIB; SWIB/MDM2 domain

cd16783
Location:430 → 486

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
XM_005164845.4 → XP_005164902.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

See identical proteins and their annotated locations for XP_005164902.1

UniProtKB/TrEMBL

A0A0R4ISQ1, A0A8M2BC69, Q561Z0

Related

ENSDARP00000138060.2, ENSDART00000162859.2

Conserved Domains (3) summary

pfam00641
Location:286 → 312

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:21 → 82

SWIB; SWIB/MDM2 domain

cd16783
Location:430 → 486

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins