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mtnr1ba melatonin receptor type 1Ba [ Danio rerio (zebrafish) ]

Gene ID: 30669, updated on 12-Sep-2024

Summary

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Official Symbol
mtnr1baprovided by ZNC
Official Full Name
melatonin receptor type 1Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-157
See related
Ensembl:ENSDARG00000053833 AllianceGenome:ZFIN:ZDB-GENE-990415-157
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mt2; mel1b; mtnr1b
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within rhythmic process and signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in diencephalic nucleus; male organism; and midbrain. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See mtnr1ba in Genome Data Viewer
Location:
chromosome: 15
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (41027466..41064007)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (41070070..41106611)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487789 Neighboring gene FAT atypical cadherin 3a Neighboring gene solute carrier family 36 member 4 Neighboring gene single-pass membrane protein with coiled-coil domains 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo. Üstündağ ÜV, et al. Sci Rep, 2019 Jul 25. PMID 31346212, Free PMC Article
  2. Cloning of a melatonin-related receptor from human pituitary. Reppert SM, et al. FEBS Lett, 1996 May 20. PMID 8647286
  3. Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Villarreal MA, et al. Zebrafish, 2017 Aug. PMID 28318435, Free PMC Article
  4. Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. Ren DL, et al. J Endocrinol, 2015 Oct. PMID 26303298
  5. Diurnal Rhythm of trek2a Expression is Associated with Diurnal Rhythm of gnrh3 Expression in Zebrafish. Loganathan K, et al. Zoolog Sci, 2019 Apr 1. PMID 31120653

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables melatonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
melatonin receptor type 1B-A
Names
mel-1B-R
mel-1B-R-A
mel1b receptor A
melatonin receptor Mel1b Z6.2
melatonin receptor Mel1b-19
melatonin receptor type 1B a
melatonin receptor type 1B z6.2
zMel1b-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131395.1 → NP_571470.1  melatonin receptor type 1B-A

    See identical proteins and their annotated locations for NP_571470.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163408
    UniProtKB/Swiss-Prot
    Q804J1, Q90456
    UniProtKB/TrEMBL
    B3DJ99, B3DJC0
    Related
    ENSDARP00000070419.3, ENSDART00000075940.4
    Conserved Domains (2) summary
    pfam00001
    Location:49 → 300
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40 → 145
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    41027466..41064007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90456.2 GenPept UniProtKB/Swiss-Prot:Q90456

Gene LinkOut

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