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elavl4 ELAV like neuron-specific RNA binding protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 30737, updated on 2-Nov-2024

Summary

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Official Symbol
elavl4provided by ZNC
Official Full Name
ELAV like neuron-specific RNA binding protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-246
See related
Ensembl:ENSDARG00000045639 AllianceGenome:ZFIN:ZDB-GENE-990415-246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hud; elrd; wu:fc24h01
Summary
Predicted to enable RNA binding activity. Acts upstream of or within axonogenesis. Part of protein-containing complex. Is expressed in heart; nervous system; swim bladder; and trigeminal placode. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See elavl4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (16004154..16116003)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (15968415..16080291)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene BEN domain containing 5 Neighboring gene AGBL carboxypeptidase 4 Neighboring gene DMRT-like family A2 Neighboring gene Fas (TNFRSF6) associated factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish. Kramer AC, et al. Front Cell Dev Biol, 2021. PMID 34790663, Free PMC Article
  2. HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation. Hao le T, et al. J Neurosci, 2017 Nov 29. PMID 29061699, Free PMC Article
  3. DeltaA mRNA and protein distribution in the zebrafish nervous system. Tallafuss A, et al. Dev Dyn, 2009 Dec. PMID 19924821, Free PMC Article
  4. Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells. Mickoleit M, et al. Dev Dyn, 2011 Mar. PMID 21337467
  5. Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention. Hufton AL, et al. Genome Res, 2009 Nov. PMID 19704032, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuD is necessary for motor axonal branch and dendrite formation.
    Title: HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axonogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon TAS
Traceable Author Statement
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
elav-related D
embryonic lethal, abnormal vision-related D
protein elrD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244600.1 → NP_001231529.1  ELAV-like protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC065965, CR931780, CU467068
    UniProtKB/Swiss-Prot
    A0A0R4IEW8, Q6NZU5, Q90409
    Related
    ENSDARP00000133629.2, ENSDART00000172510.2
    Conserved Domains (1) summary
    TIGR01661
    Location:85 → 410
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001244601.1 → NP_001231530.1  ELAV-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    BC065965, CR931780, CU467068
    UniProtKB/TrEMBL
    A0A0R4IXJ1, Q90409
    Conserved Domains (1) summary
    TIGR01661
    Location:72 → 397
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_131453.3 → NP_571528.2  ELAV-like protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    BC065965, CU467068
    UniProtKB/TrEMBL
    F1QGR7
    Related
    ENSDARP00000098371.3, ENSDART00000110171.5
    Conserved Domains (1) summary
    TIGR01661
    Location:77 → 402
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    16004154..16116003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222857.1 → XP_068078958.1  ELAV-like protein 4 isoform X2

  2. XM_068222859.1 → XP_068078960.1  ELAV-like protein 4 isoform X4

    Related
    ENSDARP00000141994.2, ENSDART00000165141.2

  3. XM_068222856.1 → XP_068078957.1  ELAV-like protein 4 isoform X1

  4. XM_068222858.1 → XP_068078959.1  ELAV-like protein 4 isoform X3

  5. XM_068222860.1 → XP_068078961.1  ELAV-like protein 4 isoform X5

  6. XM_068222863.1 → XP_068078964.1  ELAV-like protein 4 isoform X8

  7. XM_068222862.1 → XP_068078963.1  ELAV-like protein 4 isoform X7

  8. XM_068222865.1 → XP_068078966.1  ELAV-like protein 4 isoform X10

  9. XM_068222861.1 → XP_068078962.1  ELAV-like protein 4 isoform X6

  10. XM_068222864.1 → XP_068078965.1  ELAV-like protein 4 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0R4IEW8.2 GenPept UniProtKB/Swiss-Prot:A0A0R4IEW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.