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hic1l hypermethylated in cancer 1 like [ Danio rerio (zebrafish) ]

Gene ID: 30771, updated on 12-Sep-2024

Summary

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Official Symbol
hic1lprovided by ZNC
Official Full Name
hypermethylated in cancer 1 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030620-1
See related
Ensembl:ENSDARG00000045660 AllianceGenome:ZFIN:ZDB-GENE-030620-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hic1; hzp1; zfHIC1a; wu:fa03g10; zgc:153128; etID142640.25
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See hic1l in Genome Data Viewer
Location:
chromosome: 25
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25562797..25575717, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25469487..25480639, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene PHD and ring finger domains 1 Neighboring gene interferon regulatory factor 7 Neighboring gene TBC1 domain family, member 2B Neighboring gene calcium and integrin binding family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1. Bertrand S, et al. Biochim Biophys Acta, 2004 Apr 16. PMID 15093138
  2. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. Deltour S, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554746
  3. Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Grimm C, et al. Hum Mol Genet, 1999 Apr. PMID 10072440
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153128

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hypermethylated in cancer 1 like
Names
hypermethylated in cancer zinc finger/POZ-domain 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131483.2 → NP_571558.2  hypermethylated in cancer 1 like

    Status: VALIDATED

    Source sequence(s)
    AL928892, EH554811
    UniProtKB/TrEMBL
    A0A8M9PML7, A9JT69
    Related
    ENSDARP00000067137.4, ENSDART00000067138.5
    Conserved Domains (4) summary
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372 → 394
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:18 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:414 → 439
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    25562797..25575717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470449.2 → XP_021326124.1  hypermethylated in cancer 1 like isoform X1

    UniProtKB/TrEMBL
    A0A8M9PML7, A9JT69
    Conserved Domains (4) summary
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372 → 394
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:18 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:414 → 439
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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