mhc2a major histocompatibility complex class II integral membrane alpha chain gene [Danio rerio (zebrafish)] - Gene

Summary

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Official Symbol: mhc2aprovided by ZNC
Official Full Name: major histocompatibility complex class II integral membrane alpha chain geneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: a4
Annotation information: not in current annotation release
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: major histocompatibility complex class II integral membrane alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131490.1 → NP_571565.1 major histocompatibility complex class II integral membrane alpha chain precursor

See identical proteins and their annotated locations for NP_571565.1

Status: PROVISIONAL

Source sequence(s)

L19451

UniProtKB/TrEMBL

Q31362

Conserved Domains (2) summary

pfam00993
Location:30 → 107

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

cl11960
Location:111 → 204

Ig; Immunoglobulin domain