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Kash5 KASH domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308581, updated on 2-Nov-2024

Summary

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Official Symbol
Kash5provided by RGD
Official Full Name
KASH domain containing 5provided by RGD
Primary source
RGD:1561972
See related
EnsemblRapid:ENSRNOG00000025378 AllianceGenome:RGD:1561972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc155; RGD1561972; Ccdc155-ps1
Summary
Predicted to enable dynein complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; meiotic telomere clustering; and spermatogenesis. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 88. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 72.3), Muscle (RPKM 17.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kash5 in Genome Data Viewer
Location:
1q22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104805248..104827720, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95668918..95691353, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101180497..101203048, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene golgi-associated, olfactory signaling regulator Neighboring gene parathyroid hormone 2 Neighboring gene uncharacterized LOC134483103 Neighboring gene dickkopf like acrosomal protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes. Luo Y, et al. Sci Rep, 2016 Feb 4. PMID 26842404, Free PMC Article
  2. Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Lee CY, et al. Cell Rep, 2015 Apr 28. PMID 25892231, Free PMC Article
  3. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. Horn HF, et al. J Cell Biol, 2013 Sep 30. PMID 24062341, Free PMC Article
  4. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. Morimoto A, et al. J Cell Biol, 2012 Jul 23. PMID 22826121, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromosome localization to nuclear envelope involved in homologous chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
is_active_in lateral element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral element ISO
Inferred from Sequence Orthology
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in meiotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in meiotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KASH domain containing 5; protein KASH5
Names
coiled-coil domain containing 155, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432239.1 → NP_001419168.1  KASH domain containing 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZPX3

  2. NM_001432240.1 → NP_001419169.1  KASH domain containing 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001432241.1 → NP_001419170.1  KASH domain containing 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001432242.1 → NP_001419171.1  KASH domain containing 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  5. NM_001432243.1 → NP_001419172.1  KASH domain containing 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  6. NM_001432245.1 → NP_001419174.1  KASH domain containing 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  7. NM_001432246.1 → NP_001419175.1  KASH domain containing 5 isoform f

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  8. NM_001432247.1 → NP_001419176.1  KASH domain containing 5 isoform f

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104805248..104827720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278194.1 → XP_063134264.1  protein KASH5 isoform X2

  2. XM_063278191.1 → XP_063134261.1  protein KASH5 isoform X1

  3. XM_063278201.1 → XP_063134271.1  protein KASH5 isoform X4

  4. XM_063278198.1 → XP_063134268.1  protein KASH5 isoform X3

  5. XM_063278223.1 → XP_063134293.1  protein KASH5 isoform X8

  6. XM_063278212.1 → XP_063134282.1  protein KASH5 isoform X7

  7. XM_039094057.2 → XP_038949985.1  protein KASH5 isoform X6

    Related
    ENSRNOP00000037916.8, ENSRNOT00000037998.8
    Conserved Domains (2) summary
    pfam14658
    Location:78 → 145
    EF-hand_9; EF-hand domain
    pfam14662
    Location:213 → 367
    KASH_CCD; Coiled-coil region of CCDC155 or KASH

  8. XM_006229199.5 → XP_006229261.1  protein KASH5 isoform X5

    Related
    ENSRNOP00000101435.1, ENSRNOT00000138492.1
    Conserved Domains (4) summary
    pfam14658
    Location:78 → 145
    EF-hand_9; EF-hand domain
    pfam14662
    Location:197 → 388
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    pfam16046
    Location:237 → 313
    FAM76; FAM76 protein
    cl12013
    Location:223 → 385
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_005494382.2 RNA Sequence

  2. XR_005494387.2 RNA Sequence

  3. XR_005494386.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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