Depdc1b DEP domain containing 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Depdc1bprovided by RGD
Official Full Name: DEP domain containing 1Bprovided by RGD
Primary source: RGD:1305799
See related: EnsemblRapid:ENSRNOG00000010701 AllianceGenome:RGD:1305799
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cell migration and positive regulation of Wnt signaling pathway. Orthologous to human DEPDC1B (DEP domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 62.9), Spleen (RPKM 34.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (41605686..41697207)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (39891163..39963779)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (39980796..40069982)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DEP domain-containing protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107651.1 → NP_001101121.1 DEP domain-containing protein 1B

Status: PROVISIONAL

Source sequence(s)

CH473955

UniProtKB/TrEMBL

A0A8I6A996, A6I5K7, D4AA32

Related

ENSRNOP00000014270.5, ENSRNOT00000014270.7

Conserved Domains (2) summary

cd04405
Location:177 → 400

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cd04447
Location:15 → 106

DEP_BRCC3; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

41605686..41697207

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281722.1 → XP_063137792.1 DEP domain-containing protein 1B isoform X1

UniProtKB/TrEMBL

A0A8I6A996
XM_017590823.3 → XP_017446312.1 DEP domain-containing protein 1B isoform X1

UniProtKB/TrEMBL

A0A8I6A996

Conserved Domains (2) summary

cd04405
Location:150 → 373

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cl02442
Location:1 → 79

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...