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Rictor RPTOR independent companion of MTOR, complex 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310131, updated on 2-Nov-2024

Summary

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Official Symbol
Rictorprovided by RGD
Official Full Name
RPTOR independent companion of MTOR, complex 2provided by RGD
Primary source
RGD:1307224
See related
EnsemblRapid:ENSRNOG00000011341 AllianceGenome:RGD:1307224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including protein kinase binding activity; protein serine/threonine kinase activator activity; and ribosome binding activity. Involved in positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of phosphorylation. Predicted to be part of TORC2 complex. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 195.9), Adrenal (RPKM 180.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rictor in Genome Data Viewer
Location:
2q16
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (57539279..57631291)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (55811877..55903893)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (56013898..56105818)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100732 Neighboring gene uncharacterized LOC120100733 Neighboring gene complement C9 Neighboring gene FYN binding protein 1 Neighboring gene oncostatin M receptor Neighboring gene ribosomal protein L21, pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of Rictor protein and Rictor-H. pylori interaction has impact on tumor progression and prognosis in patients with gastric cancer. Wang F, et al. Folia Histochem Cytobiol, 2020. PMID 32588907
  2. Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury. Chen N, et al. FASEB J, 2020 May. PMID 32232913
  3. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network. Mok KW, et al. FASEB J, 2013 Mar. PMID 23288930, Free PMC Article
  4. MiR-424/503-mediated Rictor upregulation promotes tumor progression. Oneyama C, et al. PLoS One, 2013. PMID 24244675, Free PMC Article
  5. Molecular characterization of gallbladder cancer using somatic mutation profiling. Javle M, et al. Hum Pathol, 2014 Apr. PMID 24508317, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
    Title: Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury.
  2. upregulation of miR-424 inhibited Rictor through Akt signaling in renal tissue of diabetic nephropathy rats and high-glucose-treated human glomerular mesangial cells.
    Title: Upregulation of microRNA-424 relieved diabetic nephropathy by targeting Rictor through mTOR Complex2/Protein Kinase B signaling.
  3. Study examined mTOR variables, with attention to mTORC2 (Rictor), in Alzheimer's disease (AD) brain samples and in two mouse models, and made comparisons with results from cell- and in vitro-based experiments where Abeta is either expressed or peptide added. Authors conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD.
    Title: mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.
  4. Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis.
    Title: Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.
  5. These data provide a novel mechanistic link of Nox4-dependent activation of mTORC2 via the energy sensor AMP-activated protein kinase to increased proliferation and survival of PAVSMCs in pulmonary artery hypertension.
    Title: Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.
  6. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction
    Title: Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network.
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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rapamycin-insensitive companion of mTOR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433124.1 → NP_001420053.1  rapamycin-insensitive companion of mTOR isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  2. NM_001433125.1 → NP_001420054.1  rapamycin-insensitive companion of mTOR isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  3. NM_001433126.1 → NP_001420055.1  rapamycin-insensitive companion of mTOR isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    57539279..57631291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103527.1 → XP_038959455.1  rapamycin-insensitive companion of mTOR isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNG4, F1M4J0
    Related
    ENSRNOP00000079615.1, ENSRNOT00000109110.2
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:58 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1085 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 991
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  2. XM_008760807.2 → XP_008759029.2  rapamycin-insensitive companion of mTOR isoform X3

    Related
    ENSRNOP00000030782.7, ENSRNOT00000029565.8
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:58 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1085 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 991
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  3. XM_063282846.1 → XP_063138916.1  rapamycin-insensitive companion of mTOR isoform X2

  4. XM_039103528.1 → XP_038959456.1  rapamycin-insensitive companion of mTOR isoform X4

    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:58 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1085 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 991
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
Nucleotide Protein Strain
Heading Accession and Version

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