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Rbm46 RNA binding motif protein 46 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310548, updated on 28-Oct-2024

Summary

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Official Symbol
Rbm46provided by RGD
Official Full Name
RNA binding motif protein 46provided by RGD
Primary source
RGD:1560205
See related
EnsemblRapid:ENSRNOG00000025823 AllianceGenome:RGD:1560205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560205
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in several processes, including cell cycle switching, mitotic to meiotic cell cycle; meiotic nuclear division; and spermatid differentiation. Predicted to act upstream of or within mRNA stabilization and trophectodermal cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human RBM46 (RNA binding motif protein 46). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Testes (RPKM 70.0), Adrenal (RPKM 45.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm46 in Genome Data Viewer
Location:
2q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (170496383..170548101, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (168198324..168242011, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181828931..181874223, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pancreatic progenitor cell differentiation and proliferation factor, pseudogene 1 Neighboring gene transcription factor BTF3 homolog 4-like Neighboring gene uncharacterized LOC102555909 Neighboring gene lecithin retinol acyltransferase Neighboring gene fibrinogen gamma chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos. Wang C, et al. Stem Cells Dev, 2015 Apr 1. PMID 25397698
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle switching, mitotic to meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in female meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within trophectodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable RNA-binding protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135717.1 → NP_001129189.1  probable RNA-binding protein 46

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ACM5, A6J5U3
    Related
    ENSRNOP00000089919.1, ENSRNOT00000116504.2
    Conserved Domains (4) summary
    cd12484
    Location:60 → 137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139 → 223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235 → 308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392 → 468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    170496383..170548101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281816.1 → XP_063137886.1  probable RNA-binding protein 46 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACM5

  2. XM_017590872.3 → XP_017446361.1  probable RNA-binding protein 46 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACM5, A6J5U3
    Conserved Domains (4) summary
    cd12484
    Location:60 → 137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139 → 223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235 → 308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392 → 468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

  3. XM_039102297.2 → XP_038958225.1  probable RNA-binding protein 46 isoform X3

    UniProtKB/TrEMBL
    A6J5U3, D3ZAE2
    Related
    ENSRNOP00000094048.2, ENSRNOT00000098771.2

  4. XM_006232530.5 → XP_006232592.1  probable RNA-binding protein 46 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALR2, A6J5U3
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 464
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  5. XM_017590873.3 → XP_017446362.1  probable RNA-binding protein 46 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACM5, A6J5U3
    Conserved Domains (4) summary
    cd12484
    Location:60 → 137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139 → 223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235 → 308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392 → 468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

  6. XM_063281817.1 → XP_063137887.1  probable RNA-binding protein 46 isoform X3

    UniProtKB/TrEMBL
    D3ZAE2

  7. XM_039102296.2 → XP_038958224.1  probable RNA-binding protein 46 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALR2, A6J5U3
    Related
    ENSRNOP00000031755.5, ENSRNOT00000035846.5
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 464
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  8. XM_063281818.1 → XP_063137888.1  probable RNA-binding protein 46 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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