Smtnl1 smoothelin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smtnl1provided by RGD
Official Full Name: smoothelin-like 1provided by RGD
Primary source: RGD:1311701
See related: EnsemblRapid:ENSRNOG00000007516 AllianceGenome:RGD:1311701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311701
Summary: Predicted to enable several functions, including calmodulin binding activity; protein domain specific binding activity; and protein phosphatase 1 binding activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including blood vessel diameter maintenance; peptidyl-serine phosphorylation; and response to activity. Predicted to be located in I band; M band; and nucleus. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Orthologous to human SMTNL1 (smoothelin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 538.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90295682..90307769, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (69889010..69901096, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72207150..72219209, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that CBD1 of SMTNL1 contributes to proximity to calmodulin within A7r5 smooth muscle cells, whereas CBD2 does not play a role.
Title: In situ analysis of smoothelin-like 1 and calmodulin interactions in smooth muscle cells by proximity ligation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CH domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	ISO Inferred from Sequence Orthology more info
located_in M band	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: smoothelin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191739.2 → NP_001178668.1 smoothelin-like protein 1

See identical proteins and their annotated locations for NP_001178668.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZP11, A0A8I6ALV6, D3ZWP4

Related

ENSRNOP00000080077.1, ENSRNOT00000114989.2

Conserved Domains (1) summary

cd00014
Location:357 → 457

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90295682..90307769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234464.4 → XP_006234526.1 smoothelin-like protein 1 isoform X1

Related

ENSRNOP00000009903.5, ENSRNOT00000009903.9

Conserved Domains (1) summary

cd00014
Location:357 → 457

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...