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Tomm34 translocase of outer mitochondrial membrane 34 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311621, updated on 5-Mar-2024

Summary

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Official Symbol
Tomm34provided by RGD
Official Full Name
translocase of outer mitochondrial membrane 34provided by RGD
Primary source
RGD:1309029
See related
Ensembl:ENSRNOG00000029799 AllianceGenome:RGD:1309029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human TOMM34 (translocase of outer mitochondrial membrane 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 142.4), Thymus (RPKM 99.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tomm34 in Genome Data Viewer
Location:
3q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173148737..173165689, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152729345..152746295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160448294..160465143, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene serine/threonine kinase 4 Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 1 Neighboring gene WAP four-disulfide core domain 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. hTom34: a novel translocase for the import of proteins into human mitochondria. Nuttall SD, et al. DNA Cell Biol, 1997 Sep. PMID 9324309
  2. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. Young JC, et al. J Biol Chem, 1998 Jul 17. PMID 9660753
  3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM34
Names
translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044244.2 → NP_001037709.1  mitochondrial import receptor subunit TOM34

    See identical proteins and their annotated locations for NP_001037709.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105768
    UniProtKB/Swiss-Prot
    Q3KRD5
    UniProtKB/TrEMBL
    A0A8L2QQ52, A6JX57
    Conserved Domains (2) summary
    TIGR00990
    Location:11 → 294
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    173148737..173165689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283870.1 → XP_063139940.1  mitochondrial import receptor subunit TOM34 isoform X2

  2. XM_006235585.5 → XP_006235647.1  mitochondrial import receptor subunit TOM34 isoform X1

    See identical proteins and their annotated locations for XP_006235647.1

    UniProtKB/TrEMBL
    A0A8I6AAW4, A0A8L2QQ52, A6JX58
    Related
    ENSRNOP00000089109.1
    Conserved Domains (3) summary
    sd00006
    Location:193 → 221
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:229 → 260
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:192 → 257
    TPR_11; TPR repeat

RNA

  1. XR_005501898.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KRD5.1 GenPept UniProtKB/Swiss-Prot:Q3KRD5

Gene LinkOut

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