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Thada THADA, armadillo repeat containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 313865, updated on 2-Nov-2024

Summary

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Official Symbol
Thadaprovided by RGD
Official Full Name
THADA, armadillo repeat containingprovided by RGD
Primary source
RGD:1560519
See related
EnsemblRapid:ENSRNOG00000025899 AllianceGenome:RGD:1560519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560519
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration and tRNA nucleoside ribose methylation. Predicted to be located in endoplasmic reticulum. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 125.6), Thymus (RPKM 99.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thada in Genome Data Viewer
Location:
6q12
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15936593..16240523)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10183942..10488007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7423555..7741431, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479315 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H2 Neighboring gene uncharacterized LOC134479314 Neighboring gene uncharacterized LOC108351166 Neighboring gene zinc finger protein 36, C3H type-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. THADA Regulates the Organismal Balance between Energy Storage and Heat Production. Moraru A, et al. Dev Cell, 2017 Apr 10. PMID 28399403, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA nucleoside ribose methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (32-2'-O)-methyltransferase regulator THADA
Names
thyroid adenoma associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191769.2 → NP_001178698.1  tRNA (32-2'-O)-methyltransferase regulator THADA

    See identical proteins and their annotated locations for NP_001178698.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZTM5, D3ZVT2
    Related
    ENSRNOP00000099300.1, ENSRNOT00000162430.1
    Conserved Domains (1) summary
    pfam10350
    Location:943 → 1238
    DUF2428; Putative death-receptor fusion protein (DUF2428)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    15936593..16240523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239705.5 → XP_006239767.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTM5, D3ZVT2
    Related
    ENSRNOP00000032728.4, ENSRNOT00000038246.8
    Conserved Domains (1) summary
    pfam10350
    Location:943 → 1238
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  2. XM_006239707.5 → XP_006239769.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZTM5
    Related
    ENSRNOP00000101179.1, ENSRNOT00000150431.1
    Conserved Domains (1) summary
    pfam10350
    Location:943 → 1238
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  3. XM_039112158.2 → XP_038968086.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X5

    Conserved Domains (1) summary
    pfam10350
    Location:938 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  4. XM_063261829.1 → XP_063117899.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X4

  5. XM_039112156.2 → XP_038968084.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X3

    Conserved Domains (1) summary
    pfam10350
    Location:938 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  6. XM_039112159.2 → XP_038968087.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X6

    Conserved Domains (1) summary
    pfam10350
    Location:938 → 1114
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  7. XM_017594120.3 → XP_017449609.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTM5, D3ZVT2
    Conserved Domains (1) summary
    pfam10350
    Location:943 → 1238
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  8. XM_063261828.1 → XP_063117898.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

    UniProtKB/TrEMBL
    D3ZVT2

RNA

  1. XR_010052081.1 RNA Sequence

  2. XR_005505507.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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