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chrnb3b cholinergic receptor nicotinic beta 3 subunit b [ Danio rerio (zebrafish) ]

Gene ID: 317643, updated on 28-Oct-2024

Summary

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Official Symbol
chrnb3bprovided by ZNC
Official Full Name
cholinergic receptor nicotinic beta 3 subunit bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030102-4
See related
Ensembl:ENSDARG00000038508 AllianceGenome:ZFIN:ZDB-GENE-030102-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chrnb3
Summary
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including membrane depolarization; response to nicotine; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See chrnb3b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (41518415..41529208)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (41151161..41161954)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 6 Neighboring gene cholinergic receptor, nicotinic, beta 5b Neighboring gene integrin, alpha 6, like Neighboring gene novel immune-type receptor 14b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation by glycogen synthase kinase-3beta of the arborization field and maturation of retinotectal projection in zebrafish. Tokuoka H, et al. J Neurosci, 2002 Dec 1. PMID 12451132, Free PMC Article
  2. Neuron-specific gene manipulations to transparent zebrafish embryos. Yoshida T, et al. Methods Cell Sci, 2003. PMID 14739583
  3. Developmental role of acetylcholinesterase in impulse control in zebrafish. Parker MO, et al. Front Behav Neurosci, 2015. PMID 26528153, Free PMC Article
  4. Activation of α2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. Menelaou E, et al. Eur J Neurosci, 2014 Jul. PMID 24738729, Free PMC Article
  5. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Trede NS, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17416673, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuronal acetylcholine receptor subunit beta-3b
Names
beta 3 subunit
cholinergic receptor, nicotinic, beta 3b (neuronal)
cholinergic receptor, nicotinic, beta polypeptide 3b
nAChR-beta3
nicotinic acetylcholine receptor, beta 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173287.1 → NP_775394.1  neuronal acetylcholine receptor subunit beta-3b precursor

    See identical proteins and their annotated locations for NP_775394.1

    Status: PROVISIONAL

    Source sequence(s)
    AB087185
    UniProtKB/TrEMBL
    B3DJA0, F6NIZ7, Q8AV68
    Related
    ENSDARP00000050036.4, ENSDART00000050037.6
    Conserved Domains (3) summary
    TIGR00860
    Location:5 → 449
    LIC; Cation transporter family protein
    pfam02931
    Location:31 → 235
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:242 → 446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    41518415..41529208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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