U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EIF4E3 eukaryotic translation initiation factor 4E family member 3 [ Homo sapiens (human) ]

Gene ID: 317649, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
EIF4E3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E family member 3provided by HGNC
Primary source
HGNC:HGNC:31837
See related
Ensembl:ENSG00000163412 MIM:609896; AllianceGenome:HGNC:31837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF-4E3; eIF4E-3
Summary
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 11.9), brain (RPKM 7.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See EIF4E3 in Genome Data Viewer
Location:
3p13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71659363..71754773, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71698509..71794043, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71724565..71803924, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FOXP1 divergent transcript Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene G protein-coupled receptor 27 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome. Weiss B, et al. Nucleic Acids Res, 2021 May 21. PMID 33893802, Free PMC Article
  2. eIF4E3, a new actor in mRNA metabolism and tumor suppression. Volpon L, et al. Cell Cycle, 2013 Apr 15. PMID 23587918, Free PMC Article
  3. Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators? Mrvová S, et al. Mol Genet Genomics, 2018 Feb. PMID 28942592
  4. Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules. Frydryskova K, et al. BMC Mol Biol, 2016 Aug 30. PMID 27578149, Free PMC Article
  5. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Osborne MJ, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431134, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
    Title: m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
  2. eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.
    Title: eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.
  3. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.
    Title: Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?
  4. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules.
    Title: Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.
  5. MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma.
    Title: MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
  6. eIF4E3 impedes oncogenic transformation and its expression is lost in some cancers.
    Title: eIF4E3, a new actor in mRNA metabolism and tumor suppression.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of eukaryotic translation initiation factor 4E family member 3 (EIF4E3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC39820, MGC86971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
eukaryotic translation initiation factor 4E type 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134649.3 → NP_001128121.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001128121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC096970, AC097634, BC068443, DN990553
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000410350.1, ENST00000448225.5
    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  2. NM_001134650.1 → NP_001128122.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001128122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC097634, AL161983, BC068443, DA227887, DA394405
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000374476.3, ENST00000389826.7
    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  3. NM_001134651.2 → NP_001128123.1  eukaryotic translation initiation factor 4E type 3 isoform a

    See identical proteins and their annotated locations for NP_001128123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC097634, AC134770, AK126999, AL161983, DR159502
    Consensus CDS
    CCDS46867.1
    UniProtKB/Swiss-Prot
    B2R963, Q6NUT1, Q8N5X7
    Related
    ENSP00000393324.2, ENST00000425534.8
    Conserved Domains (1) summary
    pfam01652
    Location:48 → 198
    IF4E; Eukaryotic initiation factor 4E

  4. NM_001282886.2 → NP_001269815.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001269815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC096970, AC097634, BC068443
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000295612.3, ENST00000295612.7
    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

  5. NM_173359.5 → NP_775495.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_775495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC097634, AK313656, AL161983, BC068443
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000411762.2, ENST00000421769.6
    Conserved Domains (1) summary
    pfam01652
    Location:6 → 92
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    71659363..71754773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448061.1 → XP_047304017.1  eukaryotic translation initiation factor 4E type 3 isoform X2

  2. XM_047448060.1 → XP_047304016.1  eukaryotic translation initiation factor 4E type 3 isoform X1

  3. XM_047448063.1 → XP_047304019.1  eukaryotic translation initiation factor 4E type 3 isoform X4

  4. XM_047448062.1 → XP_047304018.1  eukaryotic translation initiation factor 4E type 3 isoform X4

  5. XM_011533651.4 → XP_011531953.1  eukaryotic translation initiation factor 4E type 3 isoform X3

    Conserved Domains (1) summary
    pfam01652
    Location:51 → 146
    IF4E; Eukaryotic initiation factor 4E

  6. XM_047448064.1 → XP_047304020.1  eukaryotic translation initiation factor 4E type 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    71698509..71794043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346403.1 → XP_054202378.1  eukaryotic translation initiation factor 4E type 3 isoform X2

  2. XM_054346402.1 → XP_054202377.1  eukaryotic translation initiation factor 4E type 3 isoform X1

  3. XM_054346405.1 → XP_054202380.1  eukaryotic translation initiation factor 4E type 3 isoform X4

  4. XM_054346404.1 → XP_054202379.1  eukaryotic translation initiation factor 4E type 3 isoform X3

  5. XM_054346406.1 → XP_054202381.1  eukaryotic translation initiation factor 4E type 3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N5X7.4 GenPept UniProtKB/Swiss-Prot:Q8N5X7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous