ttn.2 titin, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttn.2provided by ZNC
Official Full Name: titin, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030113-2
See related: AllianceGenome:ZFIN:ZDB-GENE-030113-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ttn; ttna; wu:fi04b11; wu:fi20g08; si:dz258d18.1; si:busm1-258d18.1
Summary: A structural constituent of muscle. Acts upstream of or within several processes, including heart contraction; myofibril assembly; and striated muscle tissue development. Is active in centriole; cytoplasm; and nucleus. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; somite; and testis. Used to study atrial fibrillation and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 236

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (42895816..43073959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (43093058..43272164, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primary structure of zebrafish connectin in heart and skeletal muscle
Title: Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle.
The herzschlag mutant produces a truncated ttna protein, lacking the C-terminal rod domain that is proposed to act as a thick filament scaffold, yet muscle patterning is still initiated, with grossly normal thick and thin filament assembly.
Title: The titin A-band rod domain is dispensable for initial thick filament assembly in zebrafish.
Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin.
Title: Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin.
ttna isoform, but not ttnb, is required for sarcomere assembly in the heart as well as the subsequent establishment of cardiac contractility.
Title: Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands.

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Pathways from PubChem

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General gene information

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Markers

fb97b12.x1 (e-PCR)
- UniSTS:187672

fi04b11.x1 (e-PCR)
- UniSTS:196635

fi37c03.x1 (e-PCR)
- UniSTS:204574

fd12e06.x1 (e-PCR)
- UniSTS:204131

AI588106 (e-PCR)
- UniSTS:206206

G45313 (e-PCR)
- UniSTS:106115

fb96b06.y1 (e-PCR)
- UniSTS:191901

fb96b11 (e-PCR), detects polymorphism
- UniSTS:189107

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IMP Inferred from Mutant Phenotype more info

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myofibril assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomerogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomerogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle myosin thick filament assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: titin

Names: TTN2; connectin a; pickwick; pik; titin a

XP_021334745.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

42895816..43073959 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479070.1 → XP_021334745.1 titin

UniProtKB/TrEMBL

A0A8M9QKG2

Conserved Domains (12) summary

PLN03209
Location:9027 → 9279

PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional

smart00409
Location:10758 → 10821

IG; Immunoglobulin

smart00410
Location:7364 → 7448

IG_like; Immunoglobulin like

cd00063
Location:21084 → 21174

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:3118 → 3207

I-set; Immunoglobulin I-set domain

cd00096
Location:31188 → 31243

Ig; Immunoglobulin domain

cd05748
Location:19140 → 19211

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains

cl11960
Location:30845 → 30935

Ig; Immunoglobulin domain

cl21453
Location:29594 → 29869

PKc_like; Protein Kinases, catalytic domain

cl26464
Location:30952 → 31161

Atrophin-1; Atrophin-1 family

cl26511
Location:8275 → 9136

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:11022 → 11105

I-set; Immunoglobulin I-set domain