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klhl41b kelch-like family member 41b [ Danio rerio (zebrafish) ]

Gene ID: 321064, updated on 2-Nov-2024

Summary

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Official Symbol
klhl41bprovided by ZNC
Official Full Name
kelch-like family member 41bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9875
See related
Ensembl:ENSDARG00000006757 AllianceGenome:ZFIN:ZDB-GENE-030131-9875
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb52; kbtbd10; sb:cb52; kbtbd10b; sarcosin; wu:fb24f05; wu:fc15e07
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within regulation of sarcomere organization; striated muscle cell development; and swimming behavior. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in M band; cytoskeleton; and sarcoplasmic reticulum membrane. Is expressed in adaxial cell; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See klhl41b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3680554..3690209)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (3519734..3529389)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene diencephalon/mesencephalon homeobox 1b Neighboring gene collagen, type XXVIII, alpha 2b Neighboring gene peptidylprolyl isomerase G (cyclophilin G) Neighboring gene phosphatase, orphan 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Developmental exposure to Pb(2+) induces transgenerational changes to zebrafish brain transcriptome. Meyer DN, et al. Chemosphere, 2020 Apr. PMID 31816550, Free PMC Article
  2. Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy. Gupta VA, et al. Am J Hum Genet, 2013 Dec 5. PMID 24268659, Free PMC Article
  3. Levels of 17beta-estradiol receptors expressed in embryonic and adult zebrafish following in vivo treatment of natural or synthetic ligands. Chandrasekar G, et al. PLoS One, 2010 Mar 12. PMID 20300630, Free PMC Article
  4. Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy. Jirka C, et al. Hum Mol Genet, 2019 Aug 1. PMID 30986853, Free PMC Article
  5. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. Delgado-Olguín P, et al. J Biol Chem, 2011 Apr 8. PMID 21288905, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of sarcomere organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sarcomere organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within swimming behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 41b
Names
kelch repeat and BTB (POZ) domain containing 10
kelch repeat and BTB (POZ) domain containing 10b
kelch repeat and BTB domain-containing protein 10b
kelch-like 41b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198979.1 → NP_945330.1  kelch-like protein 41b

    See identical proteins and their annotated locations for NP_945330.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054912
    UniProtKB/Swiss-Prot
    F1QEG2, Q7SYD2
    Related
    ENSDARP00000012238.5, ENSDART00000013588.7
    Conserved Domains (6) summary
    PHA03098
    Location:46 → 528
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:387 → 432
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:22 → 128
    BTB; BTB/POZ domain
    pfam01344
    Location:483 → 521
    Kelch_1; Kelch motif
    pfam07707
    Location:136 → 238
    BACK; BTB And C-terminal Kelch
    pfam13964
    Location:437 → 484
    Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    3680554..3690209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QEG2.1 GenPept UniProtKB/Swiss-Prot:F1QEG2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.