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rock2b rho-associated, coiled-coil containing protein kinase 2b [ Danio rerio (zebrafish) ]

Gene ID: 321070, updated on 2-Nov-2024

Summary

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Official Symbol
rock2bprovided by ZNC
Official Full Name
rho-associated, coiled-coil containing protein kinase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060125-2
See related
Ensembl:ENSDARG00000004877 AllianceGenome:ZFIN:ZDB-GENE-060125-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb64; sb:cb64; si:dkey-65b13.7; si:dkey-65b13.10
Summary
Predicted to enable Rho-dependent protein serine/threonine kinase activity. Acts upstream of or within Kupffer's vesicle development; epithelial cilium movement involved in determination of left/right asymmetry; and heart morphogenesis. Located in extracellular region. Is expressed in several structures, including EVL; Kupffer's vesicle; forerunner cell group; hindbrain; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See rock2b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (33575452..33705224, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (33672573..33804146, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene rho-associated protein kinase 2-like Neighboring gene si:dkey-65b13.8 Neighboring gene rho-associated protein kinase 2-like Neighboring gene golgin subfamily A member 6-like protein 24 Neighboring gene golgin subfamily A member 6-like protein 26 Neighboring gene golgin subfamily A member 6-like protein 24 Neighboring gene golgin subfamily A member 6-like protein 24 Neighboring gene si:ch211-199m3.1 Neighboring gene uncharacterized LOC110438183 Neighboring gene uncharacterized LOC103909328 Neighboring gene adenylate kinase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of gene function and visualization of cilia-generated fluid flow in Kupffer's vesicle. Wang G, et al. J Vis Exp, 2013 Mar 31. PMID 23567922, Free PMC Article
  2. Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo. Wang G, et al. Dev Biol, 2012 Oct 1. PMID 22841644, Free PMC Article
  3. The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity. Lisowska J, et al. J Cell Sci, 2018 Aug 13. PMID 30030370
  4. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. Lahne M, et al. J Neurosci, 2015 Nov 25. PMID 26609156, Free PMC Article
  5. Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo. Chu LT, et al. Biol Open, 2012 Aug 15. PMID 23213468, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-associated protein kinase 2b
Names
rho-kinase 2
NP_001087216.1
XP_017207922.1
XP_017207923.1
XP_021324031.1
XP_021324032.1
XP_021324035.1
XP_021324036.1
XP_068071478.1
XP_068071479.1
XP_068071480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093747.2 → NP_001087216.1  rho-associated protein kinase 2b

    See identical proteins and their annotated locations for NP_001087216.1

    Status: PROVISIONAL

    Source sequence(s)
    AL929220, BX571790
    UniProtKB/TrEMBL
    A0A8M1NDD8, F1R417
    Conserved Domains (7) summary
    smart00220
    Location:78 → 340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:432 → 1097
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1253 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1145 → 1249
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:967 → 1034
    Rho_Binding; Rho Binding
    cl00087
    Location:494 → 560
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    33575452..33705224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468361.2 → XP_021324036.1  rho-associated protein kinase 2b isoform X8

    UniProtKB/TrEMBL
    A0A8M9PP57
    Conserved Domains (3) summary
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cl21453
    Location:1161 → 1346
    PKc_like; Protein Kinases, catalytic domain
    cl25732
    Location:432 → 1097
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021468360.2 → XP_021324035.1  rho-associated protein kinase 2b isoform X6

    UniProtKB/TrEMBL
    A0A8M9PSI1
    Conserved Domains (3) summary
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cl21453
    Location:1228 → 1413
    PKc_like; Protein Kinases, catalytic domain
    cl25732
    Location:432 → 1097
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_068215379.1 → XP_068071480.1  rho-associated protein kinase 2b isoform X9

  4. XM_068215377.1 → XP_068071478.1  rho-associated protein kinase 2b isoform X4

  5. XM_068215378.1 → XP_068071479.1  rho-associated protein kinase 2b isoform X7

    Related
    ENSDARP00000136393.1, ENSDART00000157427.2

  6. XM_017352434.3 → XP_017207923.1  rho-associated protein kinase 2b isoform X5

    UniProtKB/TrEMBL
    A0A8M6YWK7
    Conserved Domains (7) summary
    cd11638
    Location:494 → 560
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:78 → 340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:432 → 1097
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1253 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1145 → 1249
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:967 → 1034
    Rho_Binding; Rho Binding

  7. XM_017352433.3 → XP_017207922.1  rho-associated protein kinase 2b isoform X3

    UniProtKB/TrEMBL
    A0A8M6YUR0
    Conserved Domains (7) summary
    cd11638
    Location:494 → 560
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:78 → 340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:432 → 1097
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1320 → 1374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1212 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:967 → 1034
    Rho_Binding; Rho Binding

  8. XM_021468356.2 → XP_021324031.1  rho-associated protein kinase 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M9PP53
    Conserved Domains (4) summary
    cd00029
    Location:1320 → 1374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1212 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cl25732
    Location:432 → 1097
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_021468357.2 → XP_021324032.1  rho-associated protein kinase 2b isoform X2

    UniProtKB/TrEMBL
    A0A8M9PBK6
    Conserved Domains (4) summary
    cd00029
    Location:1320 → 1374
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1212 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:51 → 402
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cl25732
    Location:432 → 1097
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_011007668.1 RNA Sequence

  2. XR_011007667.1 RNA Sequence

  3. XR_011007666.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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