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phb prohibitin [ Danio rerio (zebrafish) ]

Gene ID: 321346, updated on 28-Oct-2024

Summary

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Official Symbol
phbprovided by ZNC
Official Full Name
prohibitinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6577
See related
Ensembl:ENSDARG00000057414 AllianceGenome:ZFIN:ZDB-GENE-030131-6577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa18f07; fb09f05; sr:nyz128; wu:fa18f07; wu:fb09f05
Summary
Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and musculature system. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See phb in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15736884..15746995)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15587000..15597197)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene proline-rich transmembrane protein 2 Neighboring gene major vault protein Neighboring gene zinc finger protein 652 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. De Meulemeester AS, et al. Front Cell Dev Biol, 2022. PMID 36238691, Free PMC Article
  2. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
  3. Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Hoffmann JL, et al. Aquat Toxicol, 2006 Sep 12. PMID 16872691
  4. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
  5. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prohibitin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201297.1 → NP_958454.1  prohibitin 1

    See identical proteins and their annotated locations for NP_958454.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055384
    UniProtKB/TrEMBL
    A0A0B5JQ92, F6NM96, Q7T1D8
    Related
    ENSDARP00000074525.4, ENSDART00000080075.5
    Conserved Domains (2) summary
    smart00244
    Location:25 → 186
    PHB; prohibitin homologues
    cd03401
    Location:26 → 220
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    15736884..15746995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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