mier1a mesoderm induction early response 1a, transcriptional regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mier1aprovided by ZNC
Official Full Name: mesoderm induction early response 1a, transcriptional regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-409
See related: Ensembl:ENSDARG00000041072 AllianceGenome:ZFIN:ZDB-GENE-030131-409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mier1; zgc:56179; wu:fb30a02
Summary: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in telencephalon. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (34825749..34838397, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (34842366..34855030, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fi38h11.x1 (e-PCR)
- UniSTS:204585

AI415782 (e-PCR)
- UniSTS:206645

fb30a02 (e-PCR)
- UniSTS:189006

fb30a02.x1 (e-PCR)
- UniSTS:203098

fc49a09.y1 (e-PCR)
- UniSTS:194007

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesoderm induction early response protein 1a

Names: mesoderm induction early response 1 homolog a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199559.1 → NP_955853.1 mesoderm induction early response protein 1a

See identical proteins and their annotated locations for NP_955853.1

Status: PROVISIONAL

Source sequence(s)

BC045973

UniProtKB/TrEMBL

Q7ZV74

Related

ENSDARP00000060168.5, ENSDART00000060169.6

Conserved Domains (3) summary

smart00717
Location:275 → 320

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:275 → 319

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:169 → 220

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

34825749..34838397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356436.3 → XP_017211925.1 mesoderm induction early response protein 1a isoform X2

UniProtKB/TrEMBL

A0A0R4IM18, A0A8M6YYN4

Related

ENSDARP00000136685.1, ENSDART00000169605.3

Conserved Domains (2) summary

pfam01448
Location:169 → 220

ELM2; ELM2 domain

cl21498
Location:275 → 302

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_017356435.3 → XP_017211924.1 mesoderm induction early response protein 1a isoform X1

UniProtKB/TrEMBL

A0A8M6Z799

Conserved Domains (2) summary

pfam01448
Location:169 → 220

ELM2; ELM2 domain

cl21498
Location:275 → 301

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...