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cth cystathionase (cystathionine gamma-lyase) [ Danio rerio (zebrafish) ]

Gene ID: 322055, updated on 2-Nov-2024

Summary

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Official Symbol
cthprovided by ZNC
Official Full Name
cystathionase (cystathionine gamma-lyase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-774
See related
Ensembl:ENSDARG00000074301 AllianceGenome:ZFIN:ZDB-GENE-030131-774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb58d08; zgc:66001; zgc:85785; wu:fb48e03; wu:fb58d08
Summary
Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to act upstream of or within cysteine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cth in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (37409558..37422947, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (37431664..37445053, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495991 Neighboring gene cystathionase (cystathionine gamma-lyase), like Neighboring gene nitrilase family, member 2 Neighboring gene si:dkey-66a8.7 Neighboring gene GTP binding protein 6 (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio). Porteus CS, et al. J Physiol, 2014 Jul 15. PMID 24756639, Free PMC Article
  2. Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio. Kumai Y, et al. Pflugers Arch, 2015 Apr. PMID 24939700
  3. H(2)S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Jiang W, et al. Stroke Vasc Neurol, 2021 Jun. PMID 33246971, Free PMC Article
  4. Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. Perna AF, et al. Int J Mol Sci, 2018 Apr 29. PMID 29710830, Free PMC Article
  5. Hydrogen sulfide promotes calcium uptake in larval zebrafish. Kwong RW, et al. Am J Physiol Cell Physiol, 2015 Jul 1. PMID 25948733, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-cysteine desulfhydrase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-cystine L-cysteine-lyase (deaminating) IEA
Inferred from Electronic Annotation
more info
  
enables cystathionine gamma-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cystathionine gamma-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process via cystathionine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cystathionine gamma-lyase
NP_997769.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212604.3 → NP_997769.3  cystathionine gamma-lyase

    Status: VALIDATED

    Source sequence(s)
    BX324166, EH493556, EH596437
    UniProtKB/TrEMBL
    A0A8M1PHM3, F1QPF7
    Related
    ENSDARP00000117293.1, ENSDART00000138351.2
    Conserved Domains (2) summary
    PRK08776
    Location:19 → 400
    PRK08776; cystathionine gamma-synthase; Provisional
    pfam01053
    Location:21 → 397
    Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    37409558..37422947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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