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fah fumarylacetoacetate hydrolase (fumarylacetoacetase) [ Danio rerio (zebrafish) ]

Gene ID: 322372, updated on 2-Nov-2024

Summary

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Official Symbol
fahprovided by ZNC
Official Full Name
fumarylacetoacetate hydrolase (fumarylacetoacetase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1091
See related
Ensembl:ENSDARG00000101762 AllianceGenome:ZFIN:ZDB-GENE-030131-1091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb59b12; zgc:55316; wu:fb59b12
Summary
Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid metabolic process. Is expressed in epidermis; fin; head mesenchyme; liver; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fah in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (10589047..10633603)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (10424673..10447782, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) Neighboring gene uncharacterized LOC137496149 Neighboring gene zinc finger, AN1-type domain 6 Neighboring gene uncharacterized LOC137496091 Neighboring gene cortexin domain containing 1 Neighboring gene aryl-hydrocarbon receptor nuclear translocator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fumarylacetoacetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fumarylacetoacetase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homogentisate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tyrosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fumarylacetoacetase
NP_955895.1
XP_021333072.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199601.1 → NP_955895.1  fumarylacetoacetase

    See identical proteins and their annotated locations for NP_955895.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044366
    UniProtKB/TrEMBL
    Q6NY55, Q803S0
    Related
    ENSDARP00000149145.1, ENSDART00000182624.1
    Conserved Domains (2) summary
    pfam01557
    Location:54 → 330
    FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
    pfam09298
    Location:1 → 48
    FAA_hydrolase_N; Fumarylacetoacetase N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    10589047..10633603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477397.2 → XP_021333072.2  fumarylacetoacetase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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