ctrb.1 chymotrypsinogen B, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctrb.1provided by ZNC
Official Full Name: chymotrypsinogen B, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1171
See related: Ensembl:ENSDARG00000090428 AllianceGenome:ZFIN:ZDB-GENE-030131-1171
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctrb1; fb69e12; wu:fb61f07; wu:fb69e12
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in exocrine pancreas; heart; pancreas; and pancreatic bud. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (35076021..35078567)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (34804544..34807090)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb59d03.x1 (e-PCR)
- UniSTS:203345

fd48d12.y1 (e-PCR)
- UniSTS:195521

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chymotrypsinogen B

Names: chymotrypsinogen B1

NP_997783.1

EC 3.4.21.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212618.1 → NP_997783.1 chymotrypsinogen B precursor

See identical proteins and their annotated locations for NP_997783.1

Status: PROVISIONAL

Source sequence(s)

BC055574

UniProtKB/TrEMBL

Q7SX97

Related

ENSDARP00000036127.6, ENSDART00000037346.8

Conserved Domains (2) summary

smart00020
Location:33 → 256

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:34 → 259

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...