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cel.1 carboxyl ester lipase, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 322481, updated on 2-Nov-2024

Summary

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Official Symbol
cel.1provided by ZNC
Official Full Name
carboxyl ester lipase, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1201
See related
Ensembl:ENSDARG00000017490 AllianceGenome:ZFIN:ZDB-GENE-030131-1201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Cel; basal.1; fb62e11; zgc:66457; zgc:92042; wu:fb62e11
Summary
Predicted to enable retinyl-palmitate esterase activity; sterol ester esterase activity; and triacylglycerol lipase activity. Predicted to be involved in ceramide catabolic process and pancreatic juice secretion. Is expressed in brain; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cel.1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11401244..11411362)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11308616..11318734)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 5 Neighboring gene carboxyl ester lipase, tandem duplicate 2 Neighboring gene zgc:92275 Neighboring gene uncharacterized LOC103909427 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish. Tan KS, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Aug-Sep. PMID 33662568
  2. Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Qiu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Jun. PMID 32061751
  3. Plasmalogens improve swimming performance by modulating the expression of genes involved in amino acid and lipid metabolism, oxidative stress, and ferroptosis in an Alzheimer's disease zebrafish model. Feng J, et al. Food Funct, 2021 Nov 29. PMID 34783821
  4. Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. Sun L, et al. Int J Mol Sci, 2023 Apr 23. PMID 37175447, Free PMC Article
  5. Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Tang SL, et al. Front Genet, 2022. PMID 35991544, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC92042

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables cholinesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinyl-palmitate esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pancreatic juice secretion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxyl ester lipase, tandem duplicate 1
NP_955901.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199607.2 → NP_955901.2  carboxyl ester lipase, tandem duplicate 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BX005379
    UniProtKB/TrEMBL
    Q7SXC0
    Related
    ENSDARP00000116496.1, ENSDART00000143952.2
    Conserved Domains (1) summary
    pfam00135
    Location:25 → 517
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    11401244..11411362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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