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plg plasminogen [ Danio rerio (zebrafish) ]

Gene ID: 322691, updated on 2-Nov-2024

Summary

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Official Symbol
plgprovided by ZNC
Official Full Name
plasminogenprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1411
See related
Ensembl:ENSDARG00000023111 AllianceGenome:ZFIN:ZDB-GENE-030131-1411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb70e09
Summary
Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See plg in Genome Data Viewer
Location:
chromosome: 20
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (42688488..42702819, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (42791378..42805709, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 receptor Neighboring gene solute carrier family 22 member 2 Neighboring gene si:ch211-140l13.3 Neighboring gene uncharacterized LOC137488688 Neighboring gene G protein-coupled receptor 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish. Pontius MHH, et al. Proc Natl Acad Sci U S A, 2024 Mar 5. PMID 38408253, Free PMC Article
  2. Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors. Jendroszek A, et al. J Biol Chem, 2019 Mar 8. PMID 30651349, Free PMC Article
  3. Whole extracts of Radix Achyranthis Bidentatae and Radix Cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo. Zhou X, et al. Exp Ther Med, 2017 Mar. PMID 28450937, Free PMC Article
  4. An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Pereiro P, et al. Front Immunol, 2022. PMID 36713462, Free PMC Article
  5. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibrinolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tissue remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plasminogen
NP_958880.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201472.2 → NP_958880.2  plasminogen precursor

    Status: VALIDATED

    Source sequence(s)
    AL845424
    UniProtKB/TrEMBL
    A0A8M1PG22, F1Q890
    Related
    ENSDARP00000045815.5, ENSDART00000045816.7
    Conserved Domains (4) summary
    smart00130
    Location:281 → 361
    KR; Kringle domain
    cd00190
    Location:589 → 813
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01099
    Location:31 → 104
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00051
    Location:376 → 453
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    42688488..42702819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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