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dus1l dihydrouridine synthase 1-like (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 322715, updated on 12-Sep-2024

Summary

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Official Symbol
dus1lprovided by ZNC
Official Full Name
dihydrouridine synthase 1-like (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1435
See related
Ensembl:ENSDARG00000089260 AllianceGenome:ZFIN:ZDB-GENE-030131-1435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63748; wu:fb71f06
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See dus1l in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36222799..36232656)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36093201..36103058)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 3a Neighboring gene casein kinase 1, delta a Neighboring gene G protein pathway suppressor 1 Neighboring gene Rac family small GTPase 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
NP_955911.2
XP_005164051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199617.2 → NP_955911.2  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

    Status: VALIDATED

    Source sequence(s)
    BX897685, EH452764, EH524077, EH592252
    UniProtKB/TrEMBL
    A0A8M1PFK3, B0S7L0
    Related
    ENSDARP00000100228.2, ENSDART00000113105.3
    Conserved Domains (3) summary
    TIGR01623
    Location:420 → 455
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:35 → 267
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:37 → 315
    Dus; Dihydrouridine synthase (Dus)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    36222799..36232656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163994.4 → XP_005164051.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

    See identical proteins and their annotated locations for XP_005164051.1

    UniProtKB/TrEMBL
    Q6PD85
    Conserved Domains (3) summary
    TIGR01623
    Location:403 → 438
    put_zinc_LRP1; putative zinc finger domain, LRP1 type
    cd02801
    Location:18 → 250
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:20 → 298
    Dus; Dihydrouridine synthase (Dus)
Nucleotide Protein Strain
Heading Accession and Version

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