nansa N-acetylneuraminic acid synthase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nansaprovided by ZNC
Official Full Name: N-acetylneuraminic acid synthase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1500
See related: Ensembl:ENSDARG00000045620 AllianceGenome:ZFIN:ZDB-GENE-030131-1500
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nans; fb73c01; zgc:77126; wu:fb73c01
Summary: Predicted to enable N-acylneuraminate-9-phosphate synthase activity. Acts upstream of or within embryonic skeletal system development. Predicted to be located in extracellular region. Is expressed in several structures, including alar plate midbrain region; axis; digestive system; hatching gland; and polster. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (12335864..12344788)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (11649064..11657988)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb73c01.x1 (e-PCR)
- UniSTS:191145

fb73c01.x1 (e-PCR)
- UniSTS:191146

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acylneuraminate-9-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylneuraminic acid synthase a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_206829.1 → NP_996660.1 N-acetylneuraminic acid synthase a

See identical proteins and their annotated locations for NP_996660.1

Status: PROVISIONAL

Source sequence(s)

BC065584

UniProtKB/TrEMBL

Q6P0K4

Related

ENSDARP00000067085.5, ENSDART00000067086.6

Conserved Domains (3) summary

cd11615
Location:292 → 348

SAF_NeuB_like; C-terminal SAF domain of sialic acid synthetase

TIGR03569
Location:19 → 345

NeuB_NnaB; N-acetylneuraminate synthase

pfam03102
Location:40 → 278

NeuB; NeuB family