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aldh3a2a aldehyde dehydrogenase 3 family, member A2a [ Danio rerio (zebrafish) ]

Gene ID: 323653, updated on 2-Nov-2024

Summary

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Official Symbol
aldh3a2aprovided by ZNC
Official Full Name
aldehyde dehydrogenase 3 family, member A2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-74
See related
Ensembl:ENSDARG00000028259 AllianceGenome:ZFIN:ZDB-GENE-040718-74
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
aldh3a2; Aldh-III; zgc:92064; wu:fc06b11
Summary
Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See aldh3a2a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20830664..20839224, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20894932..20904138, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene aldehyde dehydrogenase 3 family, member A1 Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene GTPase IMAP family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative studies of vertebrate aldehyde dehydrogenase 3: sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. Holmes RS, et al. Chem Biol Interact, 2011 May 30. PMID 21296057
  2. Enantioselectivity of toxicological responses induced by maternal exposure of cis-bifenthrin enantiomers in zebrafish (Danio rerio) larvae. Xiang D, et al. J Hazard Mater, 2019 Jun 5. PMID 30889462
  3. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. Lodd E, et al. JCI Insight, 2019 Jun 20. PMID 31217350, Free PMC Article
  4. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
  5. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 3 member A2a
Names
aldehyde dehydrogenase 3 family, member A2
sls
NP_997814.1
XP_009289895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212649.1 → NP_997814.1  aldehyde dehydrogenase family 3 member A2a

    See identical proteins and their annotated locations for NP_997814.1

    Status: PROVISIONAL

    Source sequence(s)
    AF254954
    UniProtKB/TrEMBL
    A9JT25, Q90ZZ8
    Related
    ENSDARP00000037108.6, ENSDART00000031625.9
    Conserved Domains (1) summary
    cd07132
    Location:5 → 446
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    20830664..20839224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291620.4 → XP_009289895.1  aldehyde dehydrogenase family 3 member A2a isoform X1

    See identical proteins and their annotated locations for XP_009289895.1

    UniProtKB/TrEMBL
    A9JT25, Q90ZZ8
    Related
    ENSDARP00000152087.1, ENSDART00000182369.1
    Conserved Domains (1) summary
    cd07132
    Location:5 → 446
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version

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