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asph aspartate beta-hydroxylase [ Danio rerio (zebrafish) ]

Gene ID: 323659, updated on 18-Sep-2024

Summary

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Official Symbol
asphprovided by ZNC
Official Full Name
aspartate beta-hydroxylaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031112-5
See related
Ensembl:ENSDARG00000055945 AllianceGenome:ZFIN:ZDB-GENE-031112-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb971; fb69e10; fc06d04; fc95a08; wu:fb69e10; wu:fc06d04; wu:fc95a08
Summary
Predicted to enable peptidyl-aspartic acid 3-dioxygenase activity. Predicted to be involved in peptidyl-aspartic acid hydroxylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including choroidal fissure; epidermis; hatching gland; pectoral fin; and periderm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See asph in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (26656251..26682186)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (27000597..27026552)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487470 Neighboring gene microRNA 124-1 Neighboring gene tocopherol (alpha) transfer protein Neighboring gene uncharacterized LOC137487825 Neighboring gene si:dkey-181m9.8 Neighboring gene inositol monophosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. Endo Y, et al. Nat Commun, 2022 Jun 13. PMID 35697689, Free PMC Article
  2. De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis. Smith L, et al. PLoS One, 2020. PMID 32804943, Free PMC Article
  3. Molecular and functional analyses of aspolin, a fish-specific protein extremely rich in aspartic acid. Kinoshita S, et al. Mar Biotechnol (NY), 2011 Jun. PMID 20878432
  4. Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development. Armas P, et al. PLoS One, 2013. PMID 23667590, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables peptidyl-aspartic acid 3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-aspartic acid 3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within peptidyl-aspartic acid hydroxylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartyl/asparaginyl beta-hydroxylase
Names
junctin
NP_001243532.1
XP_005163439.1
XP_005163440.1
XP_005163441.1
XP_005163442.1
XP_068079102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256603.1 → NP_001243532.1  aspartyl/asparaginyl beta-hydroxylase

    Status: VALIDATED

    Source sequence(s)
    BX248497
    UniProtKB/TrEMBL
    A0A8M1P2K0, B0S5J7, E7F0Q6
    Related
    ENSDARP00000089980.4, ENSDART00000099208.5
    Conserved Domains (1) summary
    pfam05279
    Location:22 → 126
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    26656251..26682186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223001.1 → XP_068079102.1  aspartyl/asparaginyl beta-hydroxylase isoform X4

    Related
    ENSDARP00000144145.2, ENSDART00000174928.2

  2. XM_005163385.5 → XP_005163442.1  aspartyl/asparaginyl beta-hydroxylase isoform X5

    UniProtKB/TrEMBL
    A0A8M2BAJ6
    Conserved Domains (1) summary
    pfam05279
    Location:22 → 111
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  3. XM_005163382.5 → XP_005163439.1  aspartyl/asparaginyl beta-hydroxylase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAF4
    Conserved Domains (1) summary
    pfam05279
    Location:25 → 129
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  4. XM_005163383.5 → XP_005163440.1  aspartyl/asparaginyl beta-hydroxylase isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAT0
    Conserved Domains (1) summary
    pfam05279
    Location:25 → 129
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  5. XM_005163384.5 → XP_005163441.1  aspartyl/asparaginyl beta-hydroxylase isoform X3

    UniProtKB/TrEMBL
    A0A8M2BAF1
    Conserved Domains (1) summary
    pfam05279
    Location:25 → 114
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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