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waca WW domain containing adaptor with coiled-coil a [ Danio rerio (zebrafish) ]

Gene ID: 323904, updated on 12-Sep-2024

Summary

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Official Symbol
wacaprovided by ZNC
Official Full Name
WW domain containing adaptor with coiled-coil aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2624
See related
Ensembl:ENSDARG00000012577 AllianceGenome:ZFIN:ZDB-GENE-030131-2624
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wac; zgc:55755; wu:fc13f04; wu:fj68f01
Summary
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including histone ubiquitination; positive regulation of TORC1 signaling; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See waca in Genome Data Viewer
Location:
chromosome: 12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23356500..23416290)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23235281..23295071)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox a Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene MAGUK p55 scaffold protein 7a Neighboring gene uncharacterized LOC103911922 Neighboring gene BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WW domain-containing adapter protein with coiled-coil
Names
WW domain-containing adapter with a coiled-coil region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199660.1 → NP_955954.1  WW domain-containing adapter protein with coiled-coil

    See identical proteins and their annotated locations for NP_955954.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048888
    UniProtKB/Swiss-Prot
    Q6PUS1, Q7ZUK7
    Conserved Domains (1) summary
    pfam00397
    Location:124 → 151
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    23356500..23416290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306588.3 → XP_009304863.1  WW domain-containing adapter protein with coiled-coil isoform X1

    UniProtKB/TrEMBL
    A0A8M3AY70, F1QS79
    Related
    ENSDARP00000073355.3, ENSDART00000078896.6
    Conserved Domains (1) summary
    pfam00397
    Location:124 → 151
    WW; WW domain

  2. XM_005156197.3 → XP_005156254.1  WW domain-containing adapter protein with coiled-coil isoform X2

    UniProtKB/TrEMBL
    A0A8M2B2I3
    Conserved Domains (1) summary
    pfam00397
    Location:124 → 151
    WW; WW domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZUK7.1 GenPept UniProtKB/Swiss-Prot:Q7ZUK7

Gene LinkOut

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