trim33 tripartite motif containing 33 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trim33provided by ZNC
Official Full Name: tripartite motif containing 33provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2773
See related: Ensembl:ENSDARG00000016181 AllianceGenome:ZFIN:ZDB-GENE-030131-2773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mon; tif1g; cb1085; id:ibd2175; unm_t30813; wu:fc17f10; zgc:136680
Summary: Predicted to enable DNA binding activity; transferase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; leukocyte chemotaxis; and regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Is expressed in several structures, including blood vessel; germ ring; gonad; intermediate cell mass of mesoderm; and nervous system. Orthologous to human TRIM33 (tripartite motif containing 33). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (10956468..11004740, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (10918763..10967194, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production.
Title: Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production.
Cell-specific transcriptional control of mitochondrial metabolism by TIF1gamma drives erythropoiesis.
Title: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.
The authors show that tif1gamma modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 and pu.1.
Title: The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ.
TIF1gamma couples the blood-specific transcriptional complex with Pol II elongation machinery to promote the transcription elongation of erythroid genes by counteracting Pol II pausing.
Title: TIF1gamma controls erythroid cell fate by regulating transcription elongation.
transcriptional intermediary factor has a major role in the differentiation of hematopoietic cells
Title: The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.

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General gene information

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Markers

fe12g02.y1 (e-PCR)
- UniSTS:196119

fc17f10 (e-PCR)
- UniSTS:189144

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM33

Names: RING-type E3 ubiquitin transferase TRIM33; TIF1-gamma; Tif1gamma; ectodermin homolog; moonshine; transcription intermediary factor 1-gamma; tripartite motif-containing protein 33; unm t30813; vampire

NP_001002871.2

EC 2.3.2.27

XP_005166785.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002871.2 → NP_001002871.2 E3 ubiquitin-protein ligase TRIM33

Status: VALIDATED

Source sequence(s)

BX321886

UniProtKB/Swiss-Prot

Q29RE2, Q6E2N3

UniProtKB/TrEMBL

A0A8M1N103, B0S5U2

Related

ENSDARP00000025140.8, ENSDART00000020116.9

Conserved Domains (8) summary

cd05502
Location:1005 → 1130

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:338 → 464

BBC; B-Box C-terminal domain

smart00818
Location:605 → 739

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

COG5034
Location:836 → 982

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15541
Location:936 → 978

PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins

cd19830
Location:287 → 339

Bbox2_TIF1g_C-VI; B-box-type 2 zinc finger found in transcription intermediary factor 1 gamma (TIF1-gamma)

cd19847
Location:228 → 281

Bbox1_TIF1g_C-VI; B-box-type 1 zinc finger found in transcriptional intermediary factor 1 gamma (TIF1-gamma)

cd16766
Location:140 → 206

RING-HC_TIF1gamma; RING finger, HC subclass, found in transcriptional inknown asiary factor 1 gamma (TIF1gamma)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

10956468..11004740 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166728.5 → XP_005166785.1 E3 ubiquitin-protein ligase TRIM33 isoform X1

UniProtKB/Swiss-Prot

Q29RE2, Q6E2N3

UniProtKB/TrEMBL

A0A2R8Q2E8, A0A8M2BE73

Related

ENSDARP00000146766.1, ENSDART00000192594.1

Conserved Domains (9) summary

cd05502
Location:1005 → 1113

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:338 → 464

BBC; B-Box C-terminal domain

smart00336
Location:233 → 266

BBOX; B-Box-type zinc finger

smart00818
Location:605 → 739

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

smart00184
Location:144 → 172

RING; Ring finger

COG5034
Location:836 → 982

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd00021
Location:293 → 331

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15541
Location:936 → 978

PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins

pfam05349
Location:692 → 792

GATA-N; GATA-type transcription activator, N-terminal