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sgk1 serum/glucocorticoid regulated kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 324140, updated on 28-Oct-2024

Summary

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Official Symbol
sgk1provided by ZNC
Official Full Name
serum/glucocorticoid regulated kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2860
See related
Ensembl:ENSDARG00000025522 AllianceGenome:ZFIN:ZDB-GENE-030131-2860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sgk; cb1083; wu:fc20a09
Summary
Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Acts upstream of or within inflammatory response. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blood vasculature; epidermal cell; epiphysis; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See sgk1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (31640239..31693336, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (31713708..31766796, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene TBP-like 1 Neighboring gene uncharacterized LOC137489136 Neighboring gene solute carrier family 2 member 12 Neighboring gene uncharacterized LOC137489137 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene HBS1-like translational GTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. Burgon J, et al. J Immunol, 2014 Feb 15. PMID 24431232, Free PMC Article
  2. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Li Y, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276417, Free PMC Article
  3. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
  4. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Yang L, et al. Toxicol Sci, 2010 Jun. PMID 20181659
  5. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
    Title: ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk1
NP_954682.1
XP_005162356.1
XP_005162357.1
XP_005162358.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199212.1 → NP_954682.1  serine/threonine-protein kinase Sgk1

    See identical proteins and their annotated locations for NP_954682.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052134
    UniProtKB/Swiss-Prot
    Q7ZTW4
    Related
    ENSDARP00000031762.5, ENSDART00000035031.7
    Conserved Domains (2) summary
    smart00220
    Location:100 → 357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:92 → 430
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    31640239..31693336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162299.5 → XP_005162356.1  serine/threonine-protein kinase Sgk1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9E4
    Conserved Domains (2) summary
    smart00220
    Location:265 → 522
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:257 → 595
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  2. XM_005162300.5 → XP_005162357.1  serine/threonine-protein kinase Sgk1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B972
    Conserved Domains (2) summary
    smart00220
    Location:82 → 339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:74 → 412
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  3. XM_005162301.5 → XP_005162358.1  serine/threonine-protein kinase Sgk1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B9J1
    Conserved Domains (2) summary
    smart00220
    Location:81 → 338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05602
    Location:73 → 411
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395160.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    31775..37610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZTW4.1 GenPept UniProtKB/Swiss-Prot:Q7ZTW4

Gene LinkOut

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