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dnaja2b DnaJ heat shock protein family (Hsp40) member A2b [ Danio rerio (zebrafish) ]

Gene ID: 324164, updated on 12-Sep-2024

Summary

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Official Symbol
dnaja2bprovided by ZNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2884
See related
Ensembl:ENSDARG00000010745 AllianceGenome:ZFIN:ZDB-GENE-030131-2884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnaja2l; fe25a07; zgc:55714; wu:fc20g08; wu:fe25a07
Summary
Predicted to enable several functions, including ATP binding activity; heat shock protein binding activity; and unfolded protein binding activity. Predicted to act upstream of or within protein folding and response to heat. Predicted to be active in cytosol. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dnaja2b in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (6857089..6869356)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (6898127..6910394)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 2 Neighboring gene protein phosphatase 6, regulatory subunit 2b Neighboring gene uncharacterized LOC101882393 Neighboring gene kielin cysteine rich BMP regulator Neighboring gene cadherin-related family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily A member 2b
Names
DnaJ (Hsp40) homolog, subfamily A, member 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212665.1 → NP_997830.1  dnaJ homolog subfamily A member 2b

    See identical proteins and their annotated locations for NP_997830.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045437
    UniProtKB/TrEMBL
    Q7ZVS0
    Related
    ENSDARP00000010419.7, ENSDART00000018735.9
    Conserved Domains (4) summary
    cd10719
    Location:145 → 211
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:116 → 342
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:4 → 413
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:9 → 67
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    6857089..6869356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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