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fanci FA complementation group I [ Danio rerio (zebrafish) ]

Gene ID: 324185, updated on 12-Sep-2024

Summary

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Official Symbol
fanciprovided by ZNC
Official Full Name
FA complementation group Iprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2905
See related
Ensembl:ENSDARG00000026224 AllianceGenome:ZFIN:ZDB-GENE-030131-2905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc21c10; wu:fc21c10; zgc:152941
Summary
Predicted to enable DNA polymerase binding activity. Predicted to act upstream of or within DNA repair. Is expressed in central nervous system; head; heart; pectoral fin; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia and Fanconi anemia complementation group I. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fanci in Genome Data Viewer
Location:
chromosome: 25
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8447565..8479171)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8370497..8402103)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mucin 5.1, oligomeric mucus/gel-forming Neighboring gene mucin 5.2 Neighboring gene polymerase (DNA directed), gamma Neighboring gene uncharacterized LOC101885510 Neighboring gene transfer RNA arginine (anticodon UCG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article
  2. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. Ramanagoudr-Bhojappa R, et al. PLoS Genet, 2018 Dec. PMID 30540754, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC152941

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Fanconi anemia group I protein
Names
Fanconi anemia, complementation group I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077312.2 → NP_001070780.2  Fanconi anemia group I protein

    Status: VALIDATED

    Source sequence(s)
    CR854881
    UniProtKB/TrEMBL
    A0A8M1NA61, F1R3B9
    Related
    ENSDARP00000116242.1, ENSDART00000142090.3
    Conserved Domains (2) summary
    cd11720
    Location:47 → 1295
    FANCI; Fanconi anemia I protein
    pfam14674
    Location:7 → 59
    FANCI_S1-cap; FANCI solenoid 1 cap

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    8447565..8479171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470451.2 → XP_021326126.1  Fanconi anemia group I protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUU2
    Related
    ENSDART00000136530.2
    Conserved Domains (2) summary
    cd11720
    Location:47 → 1295
    FANCI; Fanconi anemia I protein
    pfam14674
    Location:7 → 59
    FANCI_S1-cap; FANCI solenoid 1 cap
Nucleotide Protein
Heading Accession and Version

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