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sp5l Sp5 transcription factor-like [ Danio rerio (zebrafish) ]

Gene ID: 324261, updated on 28-Oct-2024

Summary

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Official Symbol
sp5lprovided by ZNC
Official Full Name
Sp5 transcription factor-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2981
See related
Ensembl:ENSDARG00000115868 AllianceGenome:ZFIN:ZDB-GENE-030131-2981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Spr2; cb577; YF-335; fc23b01; sb:cb577; wu:fc23b01
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesoderm formation; notochord development; and post-anal tail morphogenesis. Is expressed in several structures, including forerunner cell group; mesoderm; nervous system; neural plate; and notochord. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See sp5l in Genome Data Viewer
Location:
chromosome: 23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28023087..28025851, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28096546..28099310, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 33Aa Neighboring gene Rho guanine nucleotide exchange factor (GEF) 25a Neighboring gene solute carrier family 26 member 10 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, like a Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling. Duncan RN, et al. Development, 2016 Jan 1. PMID 26603385, Free PMC Article
  2. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Ishimatsu K, et al. Development, 2018 Jun 11. PMID 29769221, Free PMC Article
  3. More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Azbazdar Y, et al. Front Cell Dev Biol, 2019. PMID 31803740, Free PMC Article
  4. Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Lekven AC, et al. Dev Biol, 2003 Feb 15. PMID 12591239
  5. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. Costa AM, et al. PLoS One, 2013. PMID 23840876, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sp5l mediates the functions of Fgf signals in anteroposterior patterning of the neuroectoderm during zebrafish embryogenesis.
    Title: Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo.
  2. sp5l is downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish.
    Title: Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish.
  3. sp5-like is a direct target of Wnt/beta-catenin signaling during gastrulation and, together with sp5, acts as a required mediator of the activities of wnt8 in patterning the mesoderm and neuroectoderm.
    Title: The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sp5 transcription factor-like
Names
SP1-like transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194371.2 → NP_919352.1  Sp5 transcription factor-like

    See identical proteins and their annotated locations for NP_919352.1

    Status: PROVISIONAL

    Source sequence(s)
    AY338748
    UniProtKB/TrEMBL
    Q6VMC5, Q7T2W1
    Related
    ENSDARP00000155656.1, ENSDART00000181146.1
    Conserved Domains (3) summary
    sd00017
    Location:255 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:280 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296 → 319
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    28023087..28025851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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