tmem165 transmembrane protein 165 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmem165provided by ZNC
Official Full Name: transmembrane protein 165provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3222
See related: Ensembl:ENSDARG00000034600 AllianceGenome:ZFIN:ZDB-GENE-030131-3222
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tparl; zgc:92342; wu:fc31a09; si:ch211-278f21.2
Summary: Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Acts upstream of or within osteoblast differentiation; protein N-linked glycosylation; and skeletal system development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in head; heart; and heart tube. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (22186297..22193116, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (22286624..22293443, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of several markers of cartilage and bone development suggests that Tmem165 deficiency alters both chondrocyte and osteoblast differentiation.
Title: Abnormal cartilage development and altered N-glycosylation in Tmem165-deficient zebrafish mirrors the phenotypes associated with TMEM165-CDG.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative divalent cation/proton antiporter TMEM165

Names: TPA regulated locus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212683.2 → NP_997848.1 putative divalent cation/proton antiporter TMEM165 precursor

See identical proteins and their annotated locations for NP_997848.1

Status: PROVISIONAL

Source sequence(s)

BC085662

UniProtKB/TrEMBL

B4F6Q3, F6NYZ6, Q8JJ62

Related

ENSDARP00000047623.4, ENSDART00000047624.5

Conserved Domains (3) summary

COG2119
Location:76 → 298

Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

pfam01169
Location:224 → 293

UPF0016; Uncharacterized protein family UPF0016

pfam07544
Location:157 → 188

Med9; RNA polymerase II transcription mediator complex subunit 9