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aup1 AUP1 lipid droplet regulating VLDL assembly factor [ Danio rerio (zebrafish) ]

Gene ID: 324654, updated on 17-Sep-2024

Summary

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Official Symbol
aup1provided by ZNC
Official Full Name
AUP1 lipid droplet regulating VLDL assembly factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3375
See related
Ensembl:ENSDARG00000092609 AllianceGenome:ZFIN:ZDB-GENE-030131-3375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73323; zgc:77755; wu:fc37d06
Summary
Predicted to enable ubiquitin binding activity and ubiquitin-protein transferase activator activity. Predicted to be involved in ERAD pathway; lipid droplet formation; and protein localization to lipid droplet. Predicted to be located in lipid droplet. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See aup1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (5835161..5860184)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (5528296..5553350)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene T cell leukemia homeobox 2 Neighboring gene Kazal-type serine peptidase inhibitor domain 2 Neighboring gene tubulin, beta 4B class IVb Neighboring gene lysyl oxidase-like 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of developmental regulation in the vertebrate FgfD subfamily. Jovelin R, et al. J Exp Zool B Mol Dev Evol, 2010 Jan 15. PMID 19562753, Free PMC Article
  2. Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. Wotton KR, et al. BMC Evol Biol, 2008 Jun 9. PMID 18541024, Free PMC Article
  3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipid droplet-regulating VLDL assembly factor AUP1
Names
ancient ubiquitous protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199690.2 → NP_955984.2  lipid droplet-regulating VLDL assembly factor AUP1

    See identical proteins and their annotated locations for NP_955984.2

    Status: VALIDATED

    Source sequence(s)
    BC065447
    UniProtKB/Swiss-Prot
    Q6P0U2, Q6PBN5
    Related
    ENSDARP00000054866.4, ENSDART00000054867.6
    Conserved Domains (2) summary
    cd14420
    Location:304 → 348
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:63 → 263
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    5835161..5860184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173083.5 → XP_005173140.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKB9
    Conserved Domains (2) summary
    cd14420
    Location:310 → 354
    CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
    cl17185
    Location:63 → 263
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PBN5.2 GenPept UniProtKB/Swiss-Prot:Q6PBN5

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