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cul3a cullin 3a [ Danio rerio (zebrafish) ]

Gene ID: 324655, updated on 2-Nov-2024

Summary

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Official Symbol
cul3aprovided by ZNC
Official Full Name
cullin 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3376
See related
Ensembl:ENSDARG00000038967 AllianceGenome:ZFIN:ZDB-GENE-030131-3376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cul3; wu:fc37e01
Summary
Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within heart development. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cul3a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (47644041..47681461, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (47789877..47827297, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit sigma 3b Neighboring gene dehydrogenase/reductase (SDR family) member 12-like b Neighboring gene muscleblind-like splicing regulator 1 Neighboring gene finTRIM family, member 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
  2. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Weinschutz Mendes H, et al. Cell Rep, 2023 Mar 28. PMID 36933215, Free PMC Article
  3. Comparative analysis of period genes in teleost fish genomes. Wang H. J Mol Evol, 2008 Jul. PMID 18535754
  4. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Feng L, et al. Dev Biol, 2010 Feb 1. PMID 19874812, Free PMC Article
  5. Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Chen X, et al. Biomedicines, 2021 Nov 16. PMID 34829928, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cullin-3a
Names
cullin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199691.2 → NP_955985.2  cullin-3a

    Status: VALIDATED

    Source sequence(s)
    CU570974, DT057506, EH455670
    UniProtKB/TrEMBL
    A0A8M1PBQ9, F6NVK8
    Related
    ENSDARP00000056881.3, ENSDART00000056882.4
    Conserved Domains (3) summary
    smart00182
    Location:427 → 569
    CULLIN; Cullin
    pfam00888
    Location:41 → 670
    Cullin; Cullin family
    pfam10557
    Location:706 → 766
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    47644041..47681461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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