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gpd1b glycerol-3-phosphate dehydrogenase 1b [ Danio rerio (zebrafish) ]

Gene ID: 325181, updated on 2-Nov-2024

Summary

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Official Symbol
gpd1bprovided by ZNC
Official Full Name
glycerol-3-phosphate dehydrogenase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3906
See related
Ensembl:ENSDARG00000043180 AllianceGenome:ZFIN:ZDB-GENE-030131-3906
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Gpd1; gpd1h; gpd1l; zgc:66051; zgc:85742; wu:fc58b05
Summary
Predicted to enable NAD binding activity; glycerol-3-phosphate dehydrogenase (NAD+) activity; and protein homodimerization activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including intermediate cell mass of mesoderm; neural plate; notochord; ventral mesoderm; and yolk syncytial layer. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See gpd1b in Genome Data Viewer
Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (6996046..7006925, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (6966200..6977079, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch73-213k20.5 Neighboring gene CD48 antigen-like Neighboring gene fibroblast growth factor receptor 1b, like Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D1 Neighboring gene uncharacterized LOC100535550

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
  2. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. Howarth DL, et al. PLoS Genet, 2014. PMID 24874946, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate dehydrogenase 1b
Names
glycerol-3-phosphate dehydrogenase 1 (soluble), like
glycerol-3-phosphate dehydrogenase 1h
NP_956000.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199706.1 → NP_956000.1  glycerol-3-phosphate dehydrogenase 1b

    See identical proteins and their annotated locations for NP_956000.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055382
    UniProtKB/TrEMBL
    Q7T1E0
    Related
    ENSDARP00000114396.1, ENSDART00000133143.2
    Conserved Domains (3) summary
    TIGR03376
    Location:5 → 343
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:5 → 171
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:197 → 337
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    6996046..7006925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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