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kmt2e lysine (K)-specific methyltransferase 2E [ Danio rerio (zebrafish) ]

Gene ID: 325395, updated on 17-Sep-2024

Summary

Official Symbol
kmt2eprovided by ZNC
Official Full Name
lysine (K)-specific methyltransferase 2Eprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4120
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-4120
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mll5; zgc:64223; wu:fc74b02
Summary
Predicted to enable metal ion binding activity. Is expressed in central nervous system and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See kmt2e in Genome Data Viewer
Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22424451..22472667, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22703476..22761156, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 5 Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene lysine (K)-specific demethylase 7Aa Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General protein information

Preferred Names
histone-lysine N-methyltransferase MLL5; inactive histone-lysine N-methyltransferase 2E
Names
DKEY-105O6.4
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
XP_005164966.1
XP_005164967.1
XP_009298714.1
XP_068076878.1
XP_692965.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    22424451..22472667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164910.5XP_005164967.1  inactive histone-lysine N-methyltransferase 2E isoform X4

    UniProtKB/TrEMBL
    A0A8M2BC51
    Conserved Domains (2) summary
    smart00317
    Location:344453
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15550
    Location:129172
    PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
  2. XM_005164909.5XP_005164966.1  inactive histone-lysine N-methyltransferase 2E isoform X3

    UniProtKB/TrEMBL
    A0A8M2BC59
    Conserved Domains (2) summary
    smart00317
    Location:344453
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15550
    Location:129172
    PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
  3. XM_687873.9XP_692965.5  inactive histone-lysine N-methyltransferase 2E isoform X2

    UniProtKB/TrEMBL
    A0A8N7UVB9
    Conserved Domains (2) summary
    smart00317
    Location:344453
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15550
    Location:129172
    PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
  4. XM_009300439.4XP_009298714.1  inactive histone-lysine N-methyltransferase 2E isoform X1

    See identical proteins and their annotated locations for XP_009298714.1

    UniProtKB/TrEMBL
    A0A8M9Q6C7
    Conserved Domains (3) summary
    smart00317
    Location:344453
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15550
    Location:129172
    PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
    cl26464
    Location:7061046
    Atrophin-1; Atrophin-1 family
  5. XM_068220777.1XP_068076878.1  inactive histone-lysine N-methyltransferase 2E isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199717.1: Suppressed sequence

    Description
    NM_199717.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.