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map3k4 mitogen-activated protein kinase kinase kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 325488, updated on 28-Oct-2024

Summary

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Official Symbol
map3k4provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-990603-4
See related
Ensembl:ENSDARG00000104835 AllianceGenome:ZFIN:ZDB-GENE-990603-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb135; mekk4; wu:fc83c01
Summary
Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to be involved in p38MAPK cascade. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Is expressed in several structures, including mesoderm; nervous system; neural plate; primordial germ cell; and tail bud. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See map3k4 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35787873..35844969, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35662312..35719599, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 75 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene potassium channel, subfamily K, member 1b Neighboring gene transforming, acidic coiled-coil containing protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
  2. A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences. Gates MA, et al. Genome Res, 1999 Apr. PMID 10207156
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 4
Names
MAP/ERK kinase kinase 4
XP_009305769.1
XP_009305770.1
XP_009305771.1
XP_021336557.1
XP_068069183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    35787873..35844969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480882.2 → XP_021336557.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PYS2
    Conserved Domains (1) summary
    cd06626
    Location:1239 → 1498
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_009307495.4 → XP_009305770.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B5F7
    Conserved Domains (2) summary
    smart00220
    Location:1274 → 1532
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:1273 → 1532
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_009307496.4 → XP_009305771.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AZE2
    Conserved Domains (2) summary
    smart00220
    Location:1241 → 1499
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:1240 → 1499
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_009307494.4 → XP_009305769.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IK63, A0A8M3B876
    Related
    ENSDARP00000133970.1, ENSDART00000171371.2
    Conserved Domains (2) summary
    smart00220
    Location:1275 → 1533
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:1274 → 1533
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_068213082.1 → XP_068069183.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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