marchf5l membrane-associated ring finger (C3HC4) 5, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: marchf5lprovided by ZNC
Official Full Name: membrane-associated ring finger (C3HC4) 5, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4792
See related: Ensembl:ENSDARG00000028559 AllianceGenome:ZFIN:ZDB-GENE-030131-4792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: march5; march5l; marchf5; zgc:56713; wu:fd60f03
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination; protein polyubiquitination; and regulation of mitochondrial fission. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (42500918..42519689, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (42672538..42691309, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF5

Names: E3 ubiquitin-protein ligase MARCH5; MARCH-V; RING-type E3 ubiquitin transferase MARCH5; RING-type E3 ubiquitin transferase MARCHF5; membrane-associated RING finger protein 5; membrane-associated RING-CH protein V

NP_956033.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199739.3 → NP_956033.2 E3 ubiquitin-protein ligase MARCHF5

See identical proteins and their annotated locations for NP_956033.2

Status: PROVISIONAL

Source sequence(s)

BC066555

UniProtKB/Swiss-Prot

Q6NYK8

Related

ENSDARP00000037207.6, ENSDART00000039187.8

Conserved Domains (1) summary

smart00744
Location:11 → 67

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins