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pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 326729, updated on 12-Sep-2024

Summary

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Official Symbol
pif1provided by ZNC
Official Full Name
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4928
See related
Ensembl:ENSDARG00000020289 AllianceGenome:ZFIN:ZDB-GENE-030131-4928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb934; fe11d03; zgc:56161; wu:fe11d03
Summary
Predicted to enable several functions, including 5'-3' DNA helicase activity; ATP binding activity; and DNA binding activity. Predicted to be involved in DNA duplex unwinding and DNA replication. Predicted to act upstream of or within cellular response to DNA damage stimulus and telomere maintenance. Predicted to be located in mitochondrion and nucleus. Predicted to be active in replication fork. Is expressed in ectoderm; head; optic tectum; pectoral fin musculature; and proliferative region. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pif1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (17096850..17114853, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (17425681..17443684, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 2a Neighboring gene thrombopoietin Neighboring gene artemin Neighboring gene prostaglandin E receptor 4 (subtype EP4) c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Helitron Transposons on the Sex Chromosomes of the Platyfish Xiphophorus maculatus and Their Evolution in Animal Genomes. Zhou Q, et al. Zebrafish, 2006. PMID 18248245
  2. lin9 is required for mitosis and cell survival during early zebrafish development. Kleinschmidt MA, et al. J Biol Chem, 2009 May 8. PMID 19278998, Free PMC Article
  3. Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. Chen B, et al. Front Pharmacol, 2019. PMID 31969822, Free PMC Article
  4. Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. Wang YF, et al. Int J Biol Sci, 2015. PMID 26327813, Free PMC Article
  5. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase PIF1
Names
PIF1 homolog
NP_942102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198807.1 → NP_942102.1  ATP-dependent DNA helicase PIF1

    See identical proteins and their annotated locations for NP_942102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045956
    UniProtKB/Swiss-Prot
    Q7ZV90
    Related
    ENSDARP00000022087.7, ENSDART00000006549.8
    Conserved Domains (2) summary
    pfam02689
    Location:551 → 598
    Herpes_Helicase; Helicase
    cl21455
    Location:206 → 504
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    17096850..17114853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZV90.1 GenPept UniProtKB/Swiss-Prot:Q7ZV90

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