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napab N-ethylmaleimide-sensitive factor attachment protein, alpha b [ Danio rerio (zebrafish) ]

Gene ID: 327082, updated on 2-Nov-2024

Summary

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Official Symbol
napabprovided by ZNC
Official Full Name
N-ethylmaleimide-sensitive factor attachment protein, alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5290
See related
Ensembl:ENSDARG00000020405 AllianceGenome:ZFIN:ZDB-GENE-030131-5290
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
napa; zgc:63906; wu:fa26c04
Summary
Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in several processes, including SNARE complex disassembly; glutamatergic synaptic transmission; and regulation of synaptic vesicle priming. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in head. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See napab in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44673996..44696810)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44680542..44703356)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene EH-domain containing 2b Neighboring gene uncharacterized LOC137488335 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, like Neighboring gene myelin-associated glycoprotein-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Nishiwaki Y, et al. Dev Cell, 2013 May 28. PMID 23725763
  2. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
  3. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884
  4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SNARE complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-ethylmaleimide-sensitive factor attachment protein, alpha b
Names
N-ethylmaleimide sensitive fusion protein attachment protein alpha b
alpha-snap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199766.1 → NP_956060.1  N-ethylmaleimide-sensitive factor attachment protein, alpha b

    See identical proteins and their annotated locations for NP_956060.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054568
    UniProtKB/TrEMBL
    Q6TGX1, Q7T2F5
    Related
    ENSDARP00000009285.7, ENSDART00000018625.8
    Conserved Domains (3) summary
    sd00006
    Location:114 → 151
    TPR; TPR repeat [structural motif]
    cd15832
    Location:9 → 287
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    pfam14938
    Location:9 → 288
    SNAP; Soluble NSF attachment protein, SNAP

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    44673996..44696810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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